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Literature summary extracted from

  • Perez-Pertejo, Y.; Reguera, R.M.; Villa, H.; Garcia-Estrada, C.; Balana-Fouce, R.; Pajares, M.A.; Ordonez, D.
    Leishmania donovani methionine adenosyltransferase. Role of cysteine residues in the recombinant enzyme (2003), Eur. J. Biochem., 270, 28-35.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.6 S-adenosylmethionine nonessential activator of tripolyphosphatase activity in the range of 0.005-0.100 mM Leishmania donovani

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.6 expressed in Escherichia coli XL-1Blue strain Leishmania donovani

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.6 N-ethylmaleimide time-dependent inactivation of both MAT activities Leishmania donovani
2.5.1.6 S-adenosylmethionine non competitive inhibition Leishmania donovani

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.6 48000
-
MAT II, gel filtration Leishmania donovani

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Leishmania donovani Q9U6Q8
-
-

Renatured (Commentary)

EC Number Renatured (Comment) Organism
2.5.1.6 refolding by a fourfold dilution refolding buffer up to a concentration of 2 M urea Leishmania donovani

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.6 0.058
-
tripolyphosphase activity Leishmania donovani
2.5.1.6 0.2
-
S-adenosylmethionine synthesis activity Leishmania donovani

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O
-
Leishmania donovani phosphate + diphosphate + S-adenosyl-L-methionine
-
?
2.5.1.6 tripolyphosphate + H2O
-
Leishmania donovani diphosphate + phosphate
-
?

Subunits

EC Number Subunits Comment Organism
2.5.1.6 dimer
-
Leishmania donovani

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.6 0.004
-
tripolyphosphate tripolyphosphase activity Leishmania donovani
2.5.1.6 0.032
-
S-adenosylmethionine S-adenosylmethionine synthesis activity Leishmania donovani

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.6 0.8
-
S-adenosylmethionine ATP concentrations of 0.5-5 mM Leishmania donovani
2.5.1.6 4
-
S-adenosylmethionine L-methionine concentrations of 0.5-5 mM Leishmania donovani