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Literature summary extracted from

  • Corrales, F.J.; Perez-Mato, I.; Sanchez Del Pino, M.M.; Ruiz, F.; Castro, C.; Garcia-Trevijano, E.R.; Latasa, U.; Martinez-Chantar, M.L.; Martinez-Cruz, A.; Avila, M.A.; Mato, J.M.
    Regulation of mammalian liver methionine adenosyltransferase (2002), J. Nutr., 132, 2377S-2381S.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.6 bacterial lipopolysaccharide results in the accumulation of nitrites and nitrates in serum and in the inactivation of MAT I/III Rattus norvegicus
2.5.1.6 carbon tetrachloride depletion of glutathione levels reduces MAT I/III activities in vivo Rattus norvegicus
2.5.1.6 Fumarylacetoacetate reduces MAT I/III activity Homo sapiens
2.5.1.6 hydrogen peroxide reduces MAT I/III activity Homo sapiens
2.5.1.6 hydrogen peroxide
-
 Rattus norvegicus
2.5.1.6 L-buthionine-(S,R)-sulfoximine inactivates hepatic MAT, prevented by the administration of glutathione-ethyl ester Rattus norvegicus
2.5.1.6 additional information reactive oxygen and nitrogen species induce the inactivation of MAT I/III Homo sapiens
2.5.1.6 nitric oxide inactivates hepatic MAT Rattus norvegicus
2.5.1.6 p-chloromercuribenzoate reduces MAT I/III activity Homo sapiens
2.5.1.6 S-nitrosoglutathione inactivates MATI/III by 70% Rattus norvegicus
2.5.1.6 S-nitrosoglutathione monoethyl ester inactivates Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Escherichia coli
-
-
-
2.5.1.6 Homo sapiens
-
-
-
2.5.1.6 Rattus norvegicus
-
-
-

Subunits

EC Number Subunits Comment Organism
2.5.1.6 tetramer
-
 Escherichia coli
2.5.1.6 tetramer
-
 Homo sapiens
2.5.1.6 tetramer
-
 Rattus norvegicus