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Literature summary extracted from

  • Markham, G.D.; Hafner, E.W.; White Tabor, C.; Tabor, H.
    S-Adenosylmethionine synthetase from Escherichia coli (1980), J. Biol. Chem., 255, 9082-9092.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.6 S-adenosylmethionine enhances tripolyphosphatase activity Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.6 Adenyl-5'-ylimidodiphosphate competitive with ATP Escherichia coli
2.5.1.6 diphosphate
-
 Escherichia coli
2.5.1.6 GTP
-
 Escherichia coli
2.5.1.6 phosphate
-
 Escherichia coli
2.5.1.6 S-adenosylmethionine
-
 Escherichia coli
2.5.1.6 S-carbamylcysteine competitive with methionine Escherichia coli
2.5.1.6 tripolyphosphate competitive with ATP Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.6 Co2+
-
 Escherichia coli
2.5.1.6 Cs+
-
 Escherichia coli
2.5.1.6 K+
-
 Escherichia coli
2.5.1.6 Li+
-
 Escherichia coli
2.5.1.6 Mg2+ cation concentration must be at least equal to ATP concentration for maximal activity Escherichia coli
2.5.1.6 Mn2+
-
 Escherichia coli
2.5.1.6 additional information divalent cations are required for tripolyphosphatase activity Escherichia coli
2.5.1.6 Na+
-
 Escherichia coli
2.5.1.6 NH4+
-
 Escherichia coli
2.5.1.6 Tl+
-
 Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.6 43000
-
 4 * 43000, SDS-PAGE Escherichia coli
2.5.1.6 180000
-
 gel filtration Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.6
-
 Escherichia coli

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.6 0.0022
-
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.6 2'-deoxy-ATP + L-methionine + H2O
-
 Escherichia coli ?
-
 ?
2.5.1.6 3'-deoxy-ATP + L-methionine + H2O
-
 Escherichia coli ?
-
 ?
2.5.1.6 ATP + L-methionine + H2O
-
 Escherichia coli S-adenosyl-L-methionine + phosphate + diphosphate
-
 ?
2.5.1.6 additional information ATP can be substituted by 3'-deoxy-ATP,8-bromo-ATP, formycin triphosphate, adenyl-5'yl imidodiphosphate Escherichia coli ?
-
 ?
2.5.1.6 tripolyphosphate + H2O tripolyphosphatase activity Escherichia coli diphosphate + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.6 tetramer 4 * 43000, SDS-PAGE Escherichia coli