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Literature summary extracted from

  • Chiang, P.K.; Cantoni, G.L.
    Activation of methionine for transmethylation. Purification of the S-adenosylmethionine synthetase of bakers yeast and its separation into two forms (1977), J. Biol. Chem., 252, 4506-4513.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.6 55000
-
 1 * 55000 + 1 * 60000, SDS-PAGE Saccharomyces cerevisiae
2.5.1.6 60000
-
 1 * 55000 + 1 * 60000, SDS-PAGE Saccharomyces cerevisiae
2.5.1.6 110000
-
 forms I and II, gel filtration Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Saccharomyces cerevisiae
-
 2 forms: I and II
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.6 partial, two forms: I and II Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.6 11
-
 isoenzyme II Saccharomyces cerevisiae
2.5.1.6 18.7
-
 isoenzyme I Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.6 2'-deoxy-ATP + L-methionine + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
2.5.1.6 3'-deoxy-ATP + L-methionine + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
2.5.1.6 ATP + L-ethionine + H2O
-
 Saccharomyces cerevisiae S-adenosyl-L-ethionine + phosphate + diphosphate
-
 ?
2.5.1.6 ATP + L-methionine + H2O
-
 Saccharomyces cerevisiae S-adenosyl-L-methionine + phosphate + diphosphate
-
 ?
2.5.1.6 tripolyphosphate + H2O tripolyphosphatase activity Saccharomyces cerevisiae diphosphate + phosphate
-
 ?
2.5.1.6 tripolyphosphate + H2O two isoenzymes with different behavior on exogenous S-adenosylmethionine addition Saccharomyces cerevisiae diphosphate + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.6 dimer 1 * 55000 + 1 * 60000, SDS-PAGE Saccharomyces cerevisiae