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Literature summary extracted from

  • Vincent, B.; Paitel, E.; Saftig, P.; Frobert, Y.; Hartmann, D.; De Strooper, B.; Grassi, J.; Lopez-Perez, E.; Checler, F.
    The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein (2001), J. Biol. Chem., 276, 37743-37746.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.81 additional information
-
 Mus musculus
3.4.24.81 additional information cells overexpressing ADAM10 are not responsive to phorbol ester-induced cleavage, indicating constitutive activity and not Protein kinase C induced activity Homo sapiens
3.4.24.86 phorbol ester
-
 Mus musculus
3.4.24.86 phorbol ester
-
 Homo sapiens

Application

EC Number Application Comment Organism
3.4.24.81 medicine cleavage by metalloproteinase ADAM10 of PrP cellular protein is constitutive and could inhibit the maintenance of the toxic core of the protein PrP scrapie in spongiform encephalopathies Homo sapiens
3.4.24.86 medicine putative cellular targets of a therapeutic strategy in neurodegenerative prion diseases Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.86 human embryonic kidney 293 transfectants overexpressing TACE Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.81 BB3103 0.01 mM inhibitory but not completely Homo sapiens
3.4.24.81 BB3103 0.01 mM inhibitory but not completely Mus musculus
3.4.24.81 additional information serine, thiol and acidic protease inhibitors are not inhibitory Homo sapiens
3.4.24.81 additional information serine, thiol and acidic protease inhibitors are not inhibitory Mus musculus
3.4.24.81 o-phenanthroline inhibit activity 0.1 mM Homo sapiens
3.4.24.81 o-phenanthroline inhibit activity 0.1 mM Mus musculus
3.4.24.81 TAPI 0.01 mM inhibitory but not completely Homo sapiens
3.4.24.81 TAPI 0.01 mM inhibitory but not completely Mus musculus
3.4.24.86 1,10-phenanthroline
-
 Homo sapiens
3.4.24.86 1,10-phenanthroline
-
 Mus musculus
3.4.24.86 BB3103
-
 Homo sapiens
3.4.24.86 TAPI
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.81 cell associated
-
 Mus musculus
-
-
3.4.24.81 cell associated
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.81 cellular prion protein Mus musculus constitutive protein cleavage N1 fragment + C-terminal fragment
-
 ?
3.4.24.81 cellular prion protein Homo sapiens constitutive protein cleavage N1 fragment + C-terminal fragment
-
 ?
3.4.24.81 cellular prion protein Mus musculus knock out line has 51% of reduction in N1 formation N1 fragment + C-terminal fragment
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.81 Homo sapiens
-
 cell line
-
3.4.24.81 Mus musculus
-
 mouse cell line
-
3.4.24.86 Homo sapiens
-
 HEK293 cells
-
3.4.24.86 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.81 SDS-PAGE Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.81 fibroblast cell line embryonic knock out fibroblast for ADAM10 Mus musculus
-
3.4.24.81 HEK-293 cell embryonic wild type cell line and overexpressing ADAM10 Homo sapiens
-
3.4.24.81 neuronal cell line TSM1 cell line Mus musculus
-
3.4.24.86 brain
-
 Mus musculus
-
3.4.24.86 brain
-
 Homo sapiens
-
3.4.24.86 embryo
-
 Mus musculus
-
3.4.24.86 embryo
-
 Homo sapiens
-
3.4.24.86 fibroblast
-
 Mus musculus
-
3.4.24.86 fibroblast
-
 Homo sapiens
-
3.4.24.86 kidney
-
 Mus musculus
-
3.4.24.86 kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.81 cellular prion protein constitutive protein cleavage Mus musculus N1 fragment + C-terminal fragment
-
 ?
3.4.24.81 cellular prion protein constitutive protein cleavage Homo sapiens N1 fragment + C-terminal fragment
-
 ?
3.4.24.81 cellular prion protein knock out line has 51% of reduction in N1 formation Mus musculus N1 fragment + C-terminal fragment
-
 ?
3.4.24.86 cellular prion protein PrPc + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?