Literature summary extracted from

Holms, J.; Mast, K.; Marcotte, P.; Elmore, I.; Li, J.; Pease, L.; Glaser, K.; Morgan, D.; Michaelides, M.; Davidsen, S.
Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-alpha converting enzyme (2001), Bioorg. Med. Chem. Lett., 11, 2907-2910.

Application

EC Number	Application	Comment	Organism
3.4.24.86	medicine	over-expression of TNF-alpha has been implicated in diseases such as rheumatoid arthritis, Crohn's disease, septic shock, AIDS, insulin resistance, cachexia and cancer	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.86	macrocyclic hydroxamic acid	-	Homo sapiens
3.4.24.86	MMP-1	-	Homo sapiens
3.4.24.86	MMP-2	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.86	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.86	proTNF-alpha + H2O	-	Homo sapiens	soluble TNF-alpha	-	?
3.4.24.86	transforming growth factor alpha + H2O	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)