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Literature summary extracted from

  • Zhang, Y.; Jiang, J.; Black, R.A.; Baumann, G.; Frank, S.J.
    Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation (2000), Endocrinology, 141, 4342-4348.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.86 phorbol ester
-
 Mus musculus
3.4.24.86 phorbol ester
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.86
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 cell surface
-
 Mus musculus 9986
-
3.4.24.86 cell surface
-
 Homo sapiens 9986
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Homo sapiens
-
-
-
3.4.24.86 Mus musculus
-
 mouse
-
3.4.24.86 Oryctolagus cuniculus
-
 rabbit
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.86 fibroblast
-
 Mus musculus
-
3.4.24.86 fibroblast
-
 Homo sapiens
-
3.4.24.86 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 growth hormone binding protein + H2O shedding, TACE is critical for PMA-induced GH receptor proteolysis and GHBP generation Mus musculus ?
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Oryctolagus cuniculus ?
-
 ?