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Literature summary extracted from
- Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4 (2000), J. Biol. Chem., 275, 10379-10387.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.86 | phorbol 12-myristate-13-acetate | - |
Mus musculus |  |
| 3.4.24.86 | phorbol ester | - |
Mus musculus | |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.86 | cDNA encoding mouse TACE, transfection of COS-7 cells | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | Mus musculus | - |
- |
- |
| 3.4.24.86 | Mus musculus | - |
mouse | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | embryo | - |
Mus musculus | - |
| 3.4.24.86 | fibroblast | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.86 | erbB4/HER4 + H2O | epidermal growth factor, essential function in heart and neural development, TACE is essential for regulated shedding of the HER4 JM-a receptor | Mus musculus | ? | - |
? | |
| 3.4.24.86 | proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| 3.4.24.86 | transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
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Release 2023.1 (January 2023)
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