Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Nelson, K.K.; Schlondorff, J.; Blobel, C.P.
    Evidence for an interaction of the metalloprotease-disintegrin tumor necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2.beta (1999), Biochem. J., 343, 673-680.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.86 lipopolysaccharide
-
 Homo sapiens
3.4.24.86 phorbol ester stimulates the TACE-mediated release of TNF-alpha from cells Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.86 cDNA clones coding for various segments of the TACE cytotail Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 cytoplasm cytoplasmic tail Homo sapiens 5737
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Homo sapiens
-
 human
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 beta-amyloid precursor protein + H2O shedding Homo sapiens ?
-
 ?
3.4.24.86 L-selectin + H2O shedding Homo sapiens ?
-
 ?
3.4.24.86 p75 tumour necrosis factor receptor + H2O shedding Homo sapiens ?
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
3.4.24.86 transforming growth factor alpha + H2O TGF alpha shedding Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 metalloprotease-disintegrin tumour necrosis factor alpha convertase
-
 Homo sapiens