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Literature summary extracted from

  • Milla, M.E.; Leesnitzer, M.A.; Moss, M.L.; Clay, W.C.; Carter, H.L.; Miller, A.B.; Su, J.L.; Lambert, M.H.; Willard, D.H.; Sheeley, D.M.; Kost, T.A.; Burkhart, W.; Moyer, M.; Blackburn, R.K.; Pahel, G.L.; Mitchell, J.L.; Hoffman, C.R.; Becherer, J.D.
    Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE) (1999), J. Biol. Chem., 274, 30563-30570.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.86 medicine targeting this key enzyme for therapeutic intervention in inflammatory diseases, cancer and AIDS Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.86 cDNA encoding TACE, full-length human TACE, inefficiently expressed in insect cells, baculovirus particles in Sf9 cell line from Spodoptera frugiperda Homo sapiens

General Stability

EC Number General Stability Organism
3.4.24.86 extreme salt sensitivity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.86 APMA inhibits TACE completely Homo sapiens
3.4.24.86 GW9471 hydroxamic acid competitive inhibitor that totally blocks TACE activity Homo sapiens
3.4.24.86 NaCl dramatic inhibitory effect on the activity of TACE Homo sapiens
3.4.24.86 TACE-pro domain pro domain is an inhibitor of the catalytic domain Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 cytosol cytosolic tail of TACE precedes TACE activation Homo sapiens 5829
-
3.4.24.86 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.86 TNF-alpha + H2O Homo sapiens
-
 soluble TNF-alpha
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Homo sapiens
-
 human
-
3.4.24.86 Homo sapiens
-
 MonoMac 6 cells
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.86
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.86 monocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha release of proTNFalpha from cellular membranes ?
3.4.24.86 TNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.86 5
-
 NaCl
-
 Homo sapiens