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Literature summary extracted from

  • Sandy, J.D.; Westling, J.; Kenagy, R.D.; Iruela-Arispe, M.L.; Verscharen, C.; Rodriguez-Mazaneque, J.C.; Zimmermann, D.R.; Lemire, J.M.; Fischer, J.W.; Wight, T.N.; Clowes, A.W.
    Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4 (2001), J. Biol. Chem., 276, 13372-13378.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.82 ADAMTS-1 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B11 proteins + H2O Homo sapiens
-
peptides
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B11 Homo sapiens
-
recombinant enzyme
-
3.4.24.82 Homo sapiens
-
ADAMTS-1 also cleaves versican and aggrecane
-
3.4.24.82 Homo sapiens O75173
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.82 recombinant ADAMTS-1 Homo sapiens
3.4.24.82 recombinant ADAMTS-4 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B11 aggrecan + H2O cleavage site is Glu373-Ala374 Homo sapiens 2 aggrecan fragment
-
?
3.4.24.B11 brevican + H2O clevage site is Glu395 Homo sapiens ?
-
?
3.4.24.B11 proteins + H2O
-
Homo sapiens peptides
-
?
3.4.24.B11 versican isoform V0 + H2O a second cleavage site might be Glu405-Gln406, cleavage site is Glu1428-Ala1429 in the V0 isoform, activity with recombinant and native human substrate protein Homo sapiens 2 peptides product identification ?
3.4.24.B11 versican isoform V1 + H2O a second cleavage site might be Glu405-Gln406, cleavage site is Glu441-Ala442 in the V1 isoform, activity with recombinant and native human substrate protein Homo sapiens 2 peptides product identification ?
3.4.24.82 aggrecan + H2O both ADAMTS-1 and ADAMTS-4 cleave aggrecan at the Glu441-Ala442 bond Homo sapiens fragments of aggrecan
-
?
3.4.24.82 versican + H2O both ADAMTS-1 and ADAMTS-4 cleave native human and recombinant versican at Glu441-A442, ADAMTS-4 is 5-10fold more active than ADAMTS-1 Homo sapiens fragments of versican
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B11 M12.222 Merops-ID Homo sapiens
3.4.24.82 ADAMTS-1
-
Homo sapiens