EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.23.48 | expression in Escherichia coli | Yersinia pestis |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.23.48 | D206A | proteolytic activity is abolished | Yersinia pestis |
3.4.23.48 | S99A | proteolytic activity is abolished | Yersinia pestis |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.23.48 | outer membrane | - |
Yersinia pestis | 19867 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.48 | plasminogen + H2O | Yersinia pestis | Pla belongs to the omptin family of enterobacterial surface proteases and is responsible for the highly efficient invasion of the plague bacterium from the subcutaneous infection site into the circulation | plasmin + ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.23.48 | Yersinia pestis | - |
Pla mediates bacterial invasion into human endothelial cells independently of its proteolytic activity | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.48 | plasminogen + H2O | Pla belongs to the omptin family of enterobacterial surface proteases and is responsible for the highly efficient invasion of the plague bacterium from the subcutaneous infection site into the circulation | Yersinia pestis | plasmin + ? | - |
? |