Literature summary extracted from

Tomasselli, A.G.; Qahwash, I.; Emmons, T.L.; Lu, Y.; Leone, J.W.; Lull, J.M.; Fok, K.F.; Bannow, C.A.; Smith, C.W.; Bienkowski, M.J.; Heinrikson, R.L.; Yan, R.
Employing a superior BACE1 cleavage sequence to probe cellular APP processing (2003), J. Neurochem., 84, 1006-1017.

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.23.46	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.23.46	amyloid precursor protein + H2O	i.e. APP, cleavage occurs between VKM-DA	Homo sapiens	?	-	?
3.4.23.46	additional information	APP mutants with superior cleavage sites	Homo sapiens	?	-	?
3.4.23.46	oxidized insulin B chain + H2O	-	Homo sapiens	?	-	?
3.4.23.46	Swedish variant of amyloid precursor protein + H2O	i.e. APPSw	Homo sapiens	?	-	?
3.4.23.46	ubiquitin + H2O	-	Homo sapiens	?	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)