EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.23.45 | two variants of the pro-protease domain: pro-BACE2-T1 and pro-BACE2-T2 | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.23.45 | Cu2+ | 70% inhibition at 1 mM | Homo sapiens | |
3.4.23.45 | Zn2+ | 70% inhibition at 1 mM | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.23.45 | 0.2 | - |
gamma-secretase cleavage site of notch | pH 6.5, 37°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.45 | amyloid-beta precursor protein + H2O | Homo sapiens | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.23.45 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.23.45 | two variants of the pro-protease domain: pro-BACE2-T1 and pro-BACE2-T2 | Homo sapiens |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.4.23.45 | 0.015 | - |
pro-BACE2-T1 | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.45 | amyloid-alpha pecursor protein + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.23.45 | amyloid-beta precursor protein + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.23.45 | gamma-secretase cleavage site of notch + H2O | NCH-gamma | Homo sapiens | ? | - |
? | |
3.4.23.45 | insulin B chain + H2O | only pro-BACE2-T1 | Homo sapiens | ? | - |
? | |
3.4.23.45 | kinetensin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.23.45 | Mastoparan + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.23.45 | neuropetide + H2O | Met-Lys-Arg-Ser-Arg-Gly-Pro-Ser-Pro-Arg-Arg | Homo sapiens | ? | - |
? | |
3.4.23.45 | preproenkephalin fragment 128-140 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.23.45 | preproenkephalin fragment 129-138 + H2O | ENK-1 | Homo sapiens | ? | - |
? | |
3.4.23.45 | Swedish amyloid-beta pecursor protein + H2O | - |
Homo sapiens | ? | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.23.45 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.23.45 | 6 | - |
pro-BACE2-T1 with preproenkephalin fragment 129-138 as substrate | Homo sapiens |
3.4.23.45 | 9 | 10 | pro-BACE2-T2 with gamma-secretase cleavage site of notch as substrate | Homo sapiens |
3.4.23.45 | 9.5 | - |
pro-BACE2-T1 with gamma-secretase cleavage site of notch as substrate | Homo sapiens |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
3.4.23.45 | 4 | 12 | stable, over 80% enzyme activity between pH 4 and pH 12 | Homo sapiens |