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Literature summary extracted from

  • Rothe, M.; Doth, J.
    Studies on the aminopeptidase activity of rat cathepsin H (1992), Eur. J. Biochem., 210, 759-764.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.22.16 additional information
-
additional information pH and temperature dependence of kcat/Km Rattus norvegicus
3.4.22.16 0.076
-
citrulline-4-methylcoumaryl-7-amide at 30°C Rattus norvegicus
3.4.22.16 0.097
-
Arg-4-methylcoumaryl-7-amide at 30°C Rattus norvegicus
3.4.22.16 0.321
-
benzoyl-Arg-4-methylcoumaryl-7-amide at 30°C Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.16 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.22.16 Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-/- bonds) as well as an endopeptidase mechanism: specific interactions of an anionic active site residue with the charged alpha-amino group of substrates cause transition state stabilization which proves the enzyme to act preferentially as an aminopeptidase Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.16 Arg-4-methylcoumaryl-7-amide + H2O
-
Rattus norvegicus Arg + 7-amino-4-methylcoumarin
-
ir
3.4.22.16 benzoyl-Arg-4-methylcoumaryl-7-amide + H2O
-
Rattus norvegicus benzoyl-Arg + 7-amino-4-methylcoumarin
-
ir
3.4.22.16 citrulline-4-methylcoumaryl-7-amide + H2O
-
Rattus norvegicus citrulline + 7-amino-4-methylcoumarin
-
ir

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.22.16 additional information
-
additional information pH and temperature dependence of kcat/Km Rattus norvegicus
3.4.22.16 0.63
-
benzoyl-Arg-4-methylcoumaryl-7-amide at 30°C Rattus norvegicus
3.4.22.16 3.1
-
citrulline-4-methylcoumaryl-7-amide at 30°C Rattus norvegicus
3.4.22.16 8.13
-
Arg-4-methylcoumaryl-7-amide at 30°C Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.16 6.5
-
substrates Arg-4-methylcoumaryl-7-amide and citrulline-4-methylcoumaryl-7-amide Rattus norvegicus
3.4.22.16 8
-
or higher, substrate benzoyl-Arg-4-methylcoumaryl-7-amide Rattus norvegicus