Literature summary extracted from

Rozanov, D.V.; Deryugina, E.I.; Ratnikov, B.I.; Monosov, E.Z.; Marchenko, G.N.; Quigley, J.P.; Strongin, A.Y.
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys574, the active site Glu240, and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells (2001), J. Biol. Chem., 276, 25705-25714.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.24.80	-	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.24.80	C574A	inefficient in stimulating cell adhesion, migration and invasion, mutation negatively affects cell adhesion	Homo sapiens
3.4.24.80	E240A	catalytically inactive, inefficient in stimulating cell migration and invasion	Homo sapiens
3.4.24.80	R89A	can activate matrix metalloproteinase 2	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.80	ilomastat	inhibits processing to the mature form of the enzyme	Homo sapiens

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.4.24.80	60000	-	-	Homo sapiens
3.4.24.80	60000	-	SDS-PAGE	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.80	Homo sapiens	P50281	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.80	Gelatin + H2O	-	Homo sapiens	?	-	?
3.4.24.80	progelatinase A + H2O	syn: pro-matrix metalloproteinase 2, leads to activation of progelatinase A	Homo sapiens	?	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.4.24.80	multimer	-	Homo sapiens
3.4.24.80	multimer	non-denaturating conditions, enzyme exists as a dimer or mulitmer	Homo sapiens

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
3.4.24.80	37	-	assay at	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)