Literature summary extracted from

Kadowaki, H.; Grant, M.A.
Relationship of membrane phospholipid composition, lactosylceramide molecular species, and the specificity of CMP-N-acetylneuraminate:lactosylceramide alpha 2,3-sialyltransferase to the molecular species composition of GM3 ganglioside (1995), J. Lipid Res., 36, 1274-1282.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.4.3.9	microsome	-	Rattus norvegicus	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.3.9	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.4.3.9	brain	-	Rattus norvegicus	-
2.4.3.9	neuron	brain neuron	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.3.9	CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide	brain sialyltransferase shows high activity with d18:1-16:0, d18:1-22:1, and d18:0-18:0 lactosylceramide molecular species, specificity changes when the lipid composition of the neuronal microsomal membrane resembles that of liver Golgi membrane lipids	Rattus norvegicus	CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide	i.e. ganglioside GM3	?

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Release 2023.1 (January 2023)