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Literature summary extracted from

  • Baubichon-Cortay, H.; Broquet, P.; George, P.; Louisot, P.
    Different reactivity of two brain sialyltransferases towards sulfhydryl reagents. Evidence for a thiol group involved in the nucleotide-sugar binding site of the NeuAc alpha 2-3Gal beta 1-3GalNAc alpha(2-6)sialyltransferase (1989), Glycoconjugate J., 6, 115-127.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.7 5,5'-dithiobis-(2-nitrobenzoic acid) 0.01 mM, 50% inhibition, 0.1 mM, 97% inhibition Rattus norvegicus
2.4.3.7 6,6'-dithiodinicotinic acid carboxypyridine disulfide IC50: 0.028 mM Rattus norvegicus
2.4.3.7 CMP 50 mM, strong inhibition Rattus norvegicus
2.4.3.7 Mersalyl acid 0.025 mM, 50% inhibition Rattus norvegicus
2.4.3.7 N-bromosuccinimide 5 mM, 98% inhibition Rattus norvegicus
2.4.3.7 N-ethylmaleimide 0.014 mM, 50% non-competitive inhibition, almost complete protection with 0.05 mM CMP-N-acetylneuraminate Rattus norvegicus
2.4.3.7 p-chloromercuribenzoic acid 0.036 mM, 50% inhibition, 0.1 mM, 97% inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.7 membrane
-
Rattus norvegicus 16020
-
2.4.3.7 microsome
-
Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.7 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.7 brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.7 CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
-
Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetylneuraminyl-2,6)-N-acetyl-D-galactosaminyl-R
-
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IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.3.7 0.028
-
IC50: 0.028 mM Rattus norvegicus 6,6'-dithiodinicotinic acid carboxypyridine disulfide