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Literature summary extracted from

  • Zhang, H.; Seabra, M.C.; Deisenhofer, J.
    Crystal structure of Rab geranylgeranyltransferase at 2.0 Å resolution (2000), Structure Fold. Des., 8, 241-251.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.60 at 2.0 Angstrom resolution, the beta subunit forms an alpha-alpha barrel that contains most of the residues in the active site, the alpha subunit consists of a helical domain, an immunoglobulin-like domain and a leucine-rich repeat domain, the N-terminal alpha subunit binds to the active site in the beta subunit Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.60 Zn2+ the location of the zinc ion in the beta subunit, where it is coordinated by Asp238beta, Cys240beta and His290beta, the fourth ligand is residue His2alpha Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine Rattus norvegicus enzyme crucial for membrane association and function of Rab proteins in intracellular vesicular trafficking S-geranylgeranyl-protein + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.60 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate mechanism Rattus norvegicus
a
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate enzyme is unique in the protein prenyltransferase family, consisting protein farnesyltransferase, EC 2.5.1.58, protein geranylgeranyltransferase type I, EC 2.5.1.59 and Rab geranylgeranyltransferase Rattus norvegicus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine
-
 Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
 ?
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine enzyme crucial for membrane association and function of Rab proteins in intracellular vesicular trafficking Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
 ?