Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Seabra, M.C.; Goldstein, J.L.; Sudhof, T.C.; Brown, M.S.
    Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys (1992), J. Biol. Chem., 267, 14497-14503.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.60 KCl 50% inhibition at 100 mM Rattus norvegicus
2.5.1.60 NaCl 50% inhibition at 100 mM Rattus norvegicus
2.5.1.60 NaOAc 50% inhibition at 100 mM Rattus norvegicus
2.5.1.60 Zn2+ in the presence of saturating concentrations of MgCl2 100% inhibition at 0.2 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.60 0.00002
-
 geranylgeranyl diphosphate pH 7.2, 37°C Rattus norvegicus
2.5.1.60 0.00002
-
 Rab3A pH 7.2, 37°C Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.60 Mg2+ requirement, KM 0.5 mM Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.60 38000
-
 alpha,beta, 1 * 60000 + 1 * 38000 Rattus norvegicus
2.5.1.60 60000
-
 alpha,beta, 1 * 60000 + 1 * 38000 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.60 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.60 component B Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.60 brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.60 0.03
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine
-
 Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
 ?
2.5.1.60 geranylgeranyl diphosphate + Rab1A substrate motif: -XXCC Rattus norvegicus ?
-
 ?
2.5.1.60 geranylgeranyl diphosphate + Rab3A substrate motif: -XCXC Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.60 heterodimer alpha,beta, 1 * 60000 + 1 * 38000 Rattus norvegicus