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Literature summary extracted from

  • Fukuda, M.
    beta6-N-acetylglucosaminyltransferase (IGnT) (2002), Handbook of Glycosyltransferases and Related Genes, 2002, 125-132.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.150
-
 Mus musculus
2.4.1.150 cDNA encoding IGnT is cloned from PA-1 cells, 400-amino acids protein Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.150 membrane type II transmembrane topology Mus musculus 16020
-
2.4.1.150 membrane type II transmembrane topology Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.150 additional information Homo sapiens expression of I-antigen is entirely dependent on IGnT, expression of IGnT is developmentally regulated ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.150 Homo sapiens
-
-
-
2.4.1.150 Mus musculus
-
-
-
2.4.1.150 Rattus norvegicus
-
-
-
2.4.1.150 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.150
-
 Sus scrofa
2.4.1.150 cIGnT, purified from PA-1 cells Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.150 brain IGnT is highly expressed in adult cerebellum and the frontal lobe of adult brain, also expression in fetal brain Homo sapiens
-
2.4.1.150 cerebellum IGnT is highly expressed in adult cerebellum Homo sapiens
-
2.4.1.150 colon IGnT is moderately expressed in adult colon Homo sapiens
-
2.4.1.150 gastric mucosa dIGnT Sus scrofa
-
2.4.1.150 heart IGnT is moderately expressed in adult heart Homo sapiens
-
2.4.1.150 kidney
-
 Mus musculus
-
2.4.1.150 kidney IGnT expression in fetal kidney Homo sapiens
-
2.4.1.150 liver
-
 Mus musculus
-
2.4.1.150 liver cIGnT Rattus norvegicus
-
2.4.1.150 lung IGnT expression in fetal lung Homo sapiens
-
2.4.1.150 PA-1 cell tetracarcinoma cells, IGnT mainly acts as cIGnT, but can also act as dIGnT with 6-30% of the activity of cIGnT Homo sapiens
-
2.4.1.150 prostate gland IGnT is highly expressed in adult prostata Homo sapiens
-
2.4.1.150 small intestine IGnT is moderately expressed in adult small intestine Homo sapiens
-
2.4.1.150 small intestine cIGnT is the dominant form Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.150 additional information
-
 Mus musculus ?
-
 ?
2.4.1.150 additional information 2 types of branching enzyme activities: cIGnT6 generates beta-1,6-N-acetylglucosaminyl branches at the central galactose residue, and dIGnT6 acts on peridistal galactose residues Homo sapiens ?
-
 ?
2.4.1.150 additional information 2 types of branching enzyme activities: cIGnT6 generates beta-1,6-N-acetylglucosaminyl branches at the central galactose residue, and dIGnT6 acts on peridistal galactose residues Sus scrofa ?
-
 ?
2.4.1.150 additional information expression of I-antigen is entirely dependent on IGnT, expression of IGnT is developmentally regulated Homo sapiens ?
-
 ?
2.4.1.150 UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-3)Galbeta(1-3)GalNAcalpha1-R dIGnT Sus scrofa UDP + GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-3)GalNAcalpha1-R
-
 ?
2.4.1.150 UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-3)Galbeta(1-4)Glc dIGnT Sus scrofa UDP + GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-4)Glc
-
 ?
2.4.1.150 UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-3)Galbeta(1-4)Glc(NAc)beta1-R dIGnT Sus scrofa UDP + GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-4)Glc(NAc)beta1-R
-
 ?
2.4.1.150 UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine
-
 Mus musculus ?
-
 ?
2.4.1.150 UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine
-
 Sus scrofa ?
-
 ?
2.4.1.150 UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine transfer of GlcNAc to beta1,4-linked Gal residue in a linear poly-N-acetyllactosamine with the approximate structure Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc(NAc)-R, forming Galbeta(1-4)GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-4)Glc(NAc)-R Homo sapiens ?
-
 ?