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Literature summary extracted from

  • Niedzwicki, J.G.; El Kouni, M.H.; Chu, S.H.; Cha, S.
    Pyrimidine acyclonucleosides, inhibitors of uridine phosphorylase (1981), Biochem. Pharmacol., 30, 2097-2101.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.3 2'-deoxyglycosylthymine
-
 Homo sapiens
2.4.2.3 2-deoxyglycosylthymine
-
 Homo sapiens
2.4.2.3 5-bromoacyclouridine
-
 Homo sapiens
2.4.2.3 5-fluoro-2'-deoxyuridine
-
 Homo sapiens
2.4.2.3 5-fluoroacyclouridine
-
 Homo sapiens
2.4.2.3 5-iodoacyclouridine
-
 Homo sapiens
2.4.2.3 Acyclothymidine competitive Homo sapiens
2.4.2.3 acyclouridine competitive Homo sapiens
2.4.2.3 Pyrimidine acyclonucleosides competitive Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.3 0.13
-
 phosphate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 uridine + phosphate
-
 Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.3 0.003
-
 Acyclothymidine
-
 Homo sapiens
2.4.2.3 0.005
-
 2-deoxyglycosylthymine
-
 Homo sapiens
2.4.2.3 0.013
-
 5-bromoacyclouridine
-
 Homo sapiens
2.4.2.3 0.014
-
 5-fluoroacyclouridine
-
 Homo sapiens
2.4.2.3 0.015
-
 acyclouridine
-
 Homo sapiens
2.4.2.3 0.03
-
 5-iodoacyclouridine
-
 Homo sapiens