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Literature summary extracted from

  • Focher, F.; Spadari, S.
    Thymidine phosphorylase: a two-face janus in anticancer chemotherapy (2001), Curr. Cancer Drug Targets, 1, 141-153.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.2.4
-
 Escherichia coli
2.4.2.4
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 1-(8-phosphonooctyl)-6-amino-5-bromouracil competitive Homo sapiens
2.4.2.4 1-(8-phosphonooctyl)-7-deazaxanthine competitive Homo sapiens
2.4.2.4 5-bromo-6-aminouracil
-
 Homo sapiens
2.4.2.4 5-chloro-6-[1-(imminopyrrolidinyl)methyl]uracil hydrochloride i.e. TPI, competitive Homo sapiens
2.4.2.4 6-(4-phenlybutylamino)uracil PBAU, 50% inhibition at 0.03 mM Homo sapiens
2.4.2.4 6-aminothymine
-
 Homo sapiens
2.4.2.4 7-deazaxanthine competitive, 50% inhibition at 0.04 mM Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.4 45000
-
 2 * 45000 Homo sapiens
2.4.2.4 90000
-
-
 Escherichia coli
2.4.2.4 90000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 additional information Homo sapiens role in thymidine metabolism, homeostasis, development and regeneration of central nervous system and formation of blood/brain barrier ?
-
 ?
2.4.2.4 additional information Homo sapiens angiogenic activity ?
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate Escherichia coli
-
 thymidine + phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate Homo sapiens enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts thymidine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Escherichia coli
-
-
-
2.4.2.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.4 homogeneity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.4 blood platelet
-
 Homo sapiens
-
2.4.2.4 breast tumor specimen Homo sapiens
-
2.4.2.4 colonic cancer cell
-
 Homo sapiens
-
2.4.2.4 gastrointestinal cancer cell
-
 Homo sapiens
-
2.4.2.4 lung cancer cell
-
 Homo sapiens
-
2.4.2.4 macrophage
-
 Homo sapiens
-
2.4.2.4 additional information no activity in normal brain Homo sapiens
-
2.4.2.4 ovarian cancer cell malignant tissue Homo sapiens
-
2.4.2.4 pancreatic cancer cell
-
 Homo sapiens
-
2.4.2.4 renal cell carcinoma cell
-
 Homo sapiens
-
2.4.2.4 stomach ulcer Homo sapiens
-
2.4.2.4 uterus leiomyoma Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 1-(tetrahydro-2-furanyl)-5-fluorouracil + phosphate i.e. Tegafur Homo sapiens ?
-
 ?
2.4.2.4 5'-deoxy-5-fluorouridine + phosphate
-
 Homo sapiens 5-fluorouracil + 5-deoxyribose-1-phosphate
-
 ?
2.4.2.4 additional information role in thymidine metabolism, homeostasis, development and regeneration of central nervous system and formation of blood/brain barrier Homo sapiens ?
-
 ?
2.4.2.4 additional information angiogenic activity Homo sapiens ?
-
 ?
2.4.2.4 thymidine + phosphate
-
 Escherichia coli thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate
-
 Escherichia coli thymidine + phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts Homo sapiens thymidine + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.4 dimer
-
 Escherichia coli
2.4.2.4 dimer 2 * 45000 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.4 0.00002
-
 5-chloro-6-[1-(imminopyrrolidinyl)methyl]uracil hydrochloride
-
 Homo sapiens