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Literature summary extracted from

  • Finnis, C.; Dodsworth, N.; Pollitt, C.E.; Carr, G.; Sleep, D.
    Thymidine phosphorylase activity of platelet-derived endothelial cell growth factor is responsible for endothelial cell mitogenicity (1993), Eur. J. Biochem., 212, 201-210.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.4 expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 additional information
-
 Escherichia coli
2.4.2.4 additional information iodination reduces activity, 63% inactivation after 5 min and complete inactivation after 20 min Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.4 0.11
-
 thymidine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 additional information Homo sapiens mitogenic effect, promotes endothelial cell proliferation ?
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate Escherichia coli
-
 thymidine + phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate Homo sapiens
-
 thymidine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Escherichia coli
-
-
-
2.4.2.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.4
-
 Escherichia coli
2.4.2.4 98% purity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.4 blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 additional information mitogenic effect, promotes endothelial cell proliferation Homo sapiens ?
-
 ?
2.4.2.4 thymidine + phosphate
-
 Escherichia coli thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate
-
 Escherichia coli thymidine + phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate
-
 Homo sapiens thymidine + phosphate
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.2.4 0.157
-
 thymidine
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.4 5.3
-
-
 Homo sapiens