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Literature summary extracted from

  • Pizzorno, G.; Cao, D.; Leffert, J.J.; Russell, R.L.; Zhang, D.; Handschumacher, R.E.
    Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update (2002), Biochim. Biophys. Acta, 1587, 133-144.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.3
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.3 5-benzylacyclouridine 0.01 mM, 90% inhibition of normal tissues, 40-60% inhibition of carcinoma tissue Homo sapiens
2.4.2.4 5-bromo-6-aminouracil
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.3 cytoplasmic membrane
-
 Homo sapiens
-
-
2.4.2.3 cytoskeleton associated with intermediate filament vimentin in fibroblasts and colon 26 cells Mus musculus 5856
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.3 33000
-
 4 * 33000 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 additional information Homo sapiens identical to platelet-derived endothelial cell growth factor ?
-
 ?
2.4.2.4 additional information Homo sapiens angiogenic activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Homo sapiens
-
-
-
2.4.2.3 Mus musculus
-
 NIH 3T3
-
2.4.2.4 Homo sapiens
-
 normal and tumor tissue
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.2.3 uridine + phosphate = uracil + alpha-D-ribose 1-phosphate ordered bi-bi mechanism, phosphate binds before uridine and alpha-D-ribose 1-phosphate is released after uracil Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 fibroblast
-
 Mus musculus
-
2.4.2.3 additional information present in all human tissue and tumors Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 thymidine + phosphate to a lesser extent compared to uridine Mus musculus thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 thymidine + phosphate to a lesser extent compared to uridine Homo sapiens thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
2.4.2.4 additional information identical to platelet-derived endothelial cell growth factor Homo sapiens ?
-
 ?
2.4.2.4 additional information angiogenic activity Homo sapiens ?
-
 ?
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 r

Subunits

EC Number Subunits Comment Organism
2.4.2.3 tetramer 4 * 33000 Homo sapiens