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Literature summary extracted from

  • Zimmerman, M.
    Deoxyribosyl transfer. II. Nucleoside:pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases (1964), J. Biol. Chem., 239, 2622-2627.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.4 Urea stimulates at low concentration, inhibits at high concentration, 4 M Homo sapiens
2.4.2.4 Urea stimulates at low concentration, inhibits at high concentration, 4 M Rattus norvegicus

General Stability

EC Number General Stability Organism
2.4.2.4 stable to repeated freezing and thawing Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 p-chloromercuribenzoate above 0.01 mM Homo sapiens
2.4.2.4 SO42- inhibition reversed by phosphate Escherichia coli
2.4.2.4 Urea inhibition at high concentration, 4 M, stimulation at low concentration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate Escherichia coli enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6 thymidine + phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate Homo sapiens enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6 thymidine + phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate Rattus norvegicus enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6 thymidine + phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate Escherichia coli B / ATCC 11303 enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6 thymidine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Escherichia coli
-
-
-
2.4.2.4 Escherichia coli B / ATCC 11303
-
-
-
2.4.2.4 Homo sapiens
-
-
-
2.4.2.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.4
-
 Escherichia coli
2.4.2.4
-
 Homo sapiens
2.4.2.4
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.4 liver
-
 Homo sapiens
-
2.4.2.4 liver
-
 Rattus norvegicus
-
2.4.2.4 spleen
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.4 18
-
-
 Rattus norvegicus
2.4.2.4 155
-
-
 Escherichia coli
2.4.2.4 1100
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
2.4.2.4 -20°C, phosphate buffer containing 2% mannitol, stable for over 1 year, human enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 additional information the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1 Escherichia coli ?
-
 ?
2.4.2.4 additional information the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1 Homo sapiens ?
-
 ?
2.4.2.4 additional information the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1 Rattus norvegicus ?
-
 ?
2.4.2.4 additional information the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1 Escherichia coli B / ATCC 11303 ?
-
 ?
2.4.2.4 thymidine + phosphate
-
 Escherichia coli thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate
-
 Rattus norvegicus thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate
-
 Escherichia coli B / ATCC 11303 thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6 Escherichia coli thymidine + phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6 Homo sapiens thymidine + phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6 Rattus norvegicus thymidine + phosphate
-
 ?
2.4.2.4 thymine + 2-deoxy-D-ribose 1-phosphate enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6 Escherichia coli B / ATCC 11303 thymidine + phosphate
-
 ?

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.4.2.4 6
-
 maximal stability Rattus norvegicus