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Literature summary extracted from

  • Dovey, H.F.; McKerrow, J.H.; Aldritt, S.M.; Wang, C.C.
    Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni. A potential target for chemotherapy (1986), J. Biol. Chem., 261, 944-948.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.8 mouse neuroblastoma hypoxanthine-guanine phosphoribosyltransferase cDNA clone Schistosoma mansoni

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.8 64000
-
 2 * 64000, SDS-PAGE Schistosoma mansoni
2.4.2.8 105000
-
 pore gradient electrophoresis Schistosoma mansoni

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.8 Schistosoma mansoni
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.8
-
 Schistosoma mansoni

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.8 9.25
-
 substrate hypoxanthine Schistosoma mansoni
2.4.2.8 13.25
-
 substrate guanine Schistosoma mansoni

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Schistosoma mansoni GMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Schistosoma mansoni IMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.8 dimer 2 * 64000, SDS-PAGE Schistosoma mansoni

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.8 37
-
 assay at Schistosoma mansoni