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Literature summary extracted from

  • Schmidt, R.; Wiegand, H.; Reichert, U.
    Purification and characterization of the hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae (1979), Eur. J. Biochem., 93, 355-361.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.8 guanine competitve against hypoxanthine Saccharomyces cerevisiae
2.4.2.8 hypoxanthine competitive against guanine Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.8 0.018
-
guanine
-
Saccharomyces cerevisiae
2.4.2.8 0.023
-
hypoxanthine
-
Saccharomyces cerevisiae
2.4.2.8 0.05
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.8 Mg2+ required Saccharomyces cerevisiae
2.4.2.8 Mg2+ maximal activity at: 1-10 mM Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.8 51000
-
gel filtration Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.8 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.8
-
Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.8 additional information
-
-
Saccharomyces cerevisiae

Storage Stability

EC Number Storage Stability Organism
2.4.2.8 -20°C, several months Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
Saccharomyces cerevisiae GMP + diphosphate
-
?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
Saccharomyces cerevisiae IMP + diphosphate
-
?

Subunits

EC Number Subunits Comment Organism
2.4.2.8 monomer 1 * 51000, SDS-PAGE Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.8 8.5
-
-
Saccharomyces cerevisiae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.2.8 5 9.5
-
Saccharomyces cerevisiae

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.4.2.8 additional information
-
preincubation for 10 min at pH 5.0 or pH 10.5 prior to enzyme assay at pH 8.5 does no affect the enzyme activity Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.8 0.018
-
guanine
-
Saccharomyces cerevisiae
2.4.2.8 0.023
-
hypoxanthine
-
Saccharomyces cerevisiae