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Literature summary extracted from

  • Vanderplasschen, A.; Markine-Goriaynoff, N.; Lomonte, P.; Suzuki, M.; Hiraoka, N.; Yeh, J.C.; Bureau, F.; Willems, L.; Thiry, E.; Fukuda, M.; Pastoret, P.P.
    A multipotential beta-1,6-N-acetylglucosaminyltransferase is encoded by bovine herpesvirus type 4 (2000), Proc. Natl. Acad. Sci. USA, 97, 5756-5761.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.102 functional expression in CHO cells, direction of enzyme activity onto the cell surface, a soluble chimeric enzyme form shows also core 4 6beta-GalNAc transferase activity, DNA and amino acid sequence determination Bovine gammaherpesvirus 4
2.4.1.148 functional expression in CHO cells, soluble chimeric enzyme form shows core 4 6beta-GalNAc transferase activity, DNA and amino acid sequence determination Bovine gammaherpesvirus 4

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.102 Bovine gammaherpesvirus 4 Q9IZK2 i.e. BHV-4
-
2.4.1.148 Bovine gammaherpesvirus 4 Q9IZK2 i.e. BHV-4
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.102 additional information expression during virus replication cycle, MDBK cells Bovine gammaherpesvirus 4
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
-
 Bovine gammaherpesvirus 4 UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R enzyme shows both core 2 beta6-GalNAc-transferase activity, EC 2.4.1.102, and core 4 beta6-GalNAc-transferase activity, EC 2.4.1.148, and is termed a type M core 2 beta6-GalNAc-transferase Bovine gammaherpesvirus 4 UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R i.e. core 4 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R i.e. core 3 Bovine gammaherpesvirus 4 UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R i.e. core 4 ?
2.4.1.148 UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-p-nitrophenol recombinant chimeric soluble enzyme Bovine gammaherpesvirus 4 UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-p-nitrophenol
-
 ?
2.4.1.148 UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R enzyme shows both core 2 beta6-GalNAc-transferase activity, EC 2.4.1.102, and core 4 beta6-GalNAc-transferase activity, EC 2.4.1.148, and is termed a type M core 2 beta6-GalNAc-transferase Bovine gammaherpesvirus 4 UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
 ?
2.4.1.148 UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R i.e. core 3 Bovine gammaherpesvirus 4 UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.102 More core 2 beta6-GalNAc-transferase, EC 2.4.1.102, exists in 2 types, type L and type M, the latter shows an additional core 4 beta6-GalNAc transferase activity Bovine gammaherpesvirus 4
2.4.1.102 More cf. EC 2.4.1.146-148 Bovine gammaherpesvirus 4
2.4.1.148 More core 2 beta6-GalNAc-transferase, EC 2.4.1.102, exists in 2 types, type L and type M, the latter shows an additional core 4 beta6-GalNAc transferase activity Bovine gammaherpesvirus 4