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Literature summary extracted from

  • Chou, D.K.H.; Jungalwala, F.B.
    N-acetylglucosaminyl Transferase regulates the expression of sulfoglucuronyl glycolipids in specific cell types in cerebellum during development (1996), J. Biol. Chem., 271, 28868-28874.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.206 UDP-N-acetyl-D-glucosamine + lactosylceramide Mus musculus glycolipid biosynthesis UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + lactosylceramide Rattus norvegicus glycolipid biosynthesis UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.206 Mus musculus
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 enzyme-deficient mutant and normal littermate mice
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2.4.1.206 Rattus norvegicus
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 Sprague-Dawley albino
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2.4.1.275 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.206 brain
-
 Mus musculus
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2.4.1.206 brain
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 Rattus norvegicus
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2.4.1.206 cerebellar Purkinje cell and dendrites Rattus norvegicus
-
2.4.1.206 cerebellum
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 Mus musculus
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2.4.1.206 cerebellum distinct cellular layers: Purkinje cell layer, molecular cell layer, granule cell layer + white matter Rattus norvegicus
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2.4.1.206 granulocyte
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 Rattus norvegicus
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2.4.1.275 cerebellar Purkinje cell the specific activities of Gal-Tr is nearly normal or slightly elevated in all the three Purkinje cell abnormality mutants Rattus norvegicus
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2.4.1.275 cerebellum specific activities of Gal-Tr in the granule cell layer and white matter is approximately 66% of that in the molecular layer. Gal-Tr in the homogenate of cerebellum declines by approximately 35-45% from postnatal day 3 to 14. Gal-Tr activity in the granule cells does not change with age. The relative Gal-Tr activity in granule cells to homogenate is between 0.13 and 0.23 Rattus norvegicus
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.206 0.00000009
-
 granule cells, 14 days old Rattus norvegicus
2.4.1.206 0.0000001
-
 cerebellum homogenate of 3 days old organisms Rattus norvegicus
2.4.1.206 0.00000015
-
 granule cells, 3 days old Rattus norvegicus
2.4.1.206 0.00000042
-
 cerebellum homogenate of 14 days old organisms Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide i.e. lactosylceramide Mus musculus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide i.e. lactosylceramide Rattus norvegicus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + lactosylceramide glycolipid biosynthesis Mus musculus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + lactosylceramide glycolipid biosynthesis Rattus norvegicus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.206 lactosylceramide: N-acetylglucosaminyltransferase
-
 Mus musculus
2.4.1.206 lactosylceramide: N-acetylglucosaminyltransferase
-
 Rattus norvegicus
2.4.1.275 lactotriaosylceramide:galactosyltransferase
-
 Rattus norvegicus
2.4.1.275 LcOse3Cer:Gal-Tr
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.4.1.275 physiological function the enzyme is involved in the synthesis of sulfoglucuronyl glycolipids Rattus norvegicus