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Literature summary extracted from

  • Baerson, S.R.; Rodriguez, D.J.; Tran, M.; Feng, Y.; Biest, N.A.; Dill, G.M.
    Glyphosate-resistant goosegrass. Identification of a mutation in the target enzyme 5-enolpyruvylshikimate-3-phosphate synthase (2002), Plant Physiol., 129, 1265-1275.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.19 P106S glyphosate-insensitive Eleusine indica
2.5.1.19 P381L similiar glyphosate sensitivity like wild-type Eleusine indica

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.19 N-phosphonomethylglycine 0.006 mM, 50% inhibition of glyphosate-sensitve strain, 0.03 mM, 50% inhibition of glyphosate-resistant strain Eleusine indica
2.5.1.19 N-phosphonomethylglycine
-
Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.19 0.0038
-
phosphoenolpyruvate glyphosate-sensitive strain Eleusine indica
2.5.1.19 0.007
-
phosphoenolpyruvate glyphosate-resistant strain Eleusine indica

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.19 Eleusine indica
-
goosegrass
-
2.5.1.19 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.19 phosphoenolpyruvate + 3-phosphoshikimate
-
Salmonella enterica subsp. enterica serovar Typhimurium phosphate + 5-enolpyruvylshikimate 3-phosphate
-
r
2.5.1.19 phosphoenolpyruvate + 3-phosphoshikimate
-
Eleusine indica phosphate + 5-enolpyruvylshikimate 3-phosphate
-
r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.19 0.00076
-
N-phosphonomethylglycine glyphosate-resistant strain Eleusine indica
2.5.1.19 0.001
-
N-phosphonomethylglycine P106S mutant enzyme Eleusine indica
2.5.1.19 0.029
-
N-phosphonomethylglycine P381L mutant enzyme Eleusine indica
2.5.1.19 0.048
-
N-phosphonomethylglycine glyphosate-sensitive strain Eleusine indica