Literature summary extracted from

Huynh, Q.K.
5-Enolpyruvylshikimate-3-phosphate synthase from Escherichia coli--the substrate analogue bromopyruvate inactivates the enzyme by modifying Cys-408 and Lys-411 (1991), Arch. Biochem. Biophys., 284, 407-412.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.5.1.19	3-Bromopyruvate	0.1 mM, approx. 80% inactivation after 5 min, maximum rate-constant: 0.31/min, substrates or a combination of shikimate 3-phosphat and glyphosate protect from inactivation, bromopyruvate modifies residues C408 and L411	Escherichia coli
2.5.1.19	N-phosphonomethylglycine	-	Escherichia coli

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.19	Escherichia coli	-	-	-
2.5.1.19	Escherichia coli N5259	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.19	phosphoenolpyruvate + 3-phosphoshikimate	-	Escherichia coli	phosphate + 5-enolpyruvylshikimate 3-phosphate	i.e. 5-O-(1-carboxyvinyl)-3-phosphoshikimate	r
2.5.1.19	phosphoenolpyruvate + 3-phosphoshikimate	-	Escherichia coli N5259	phosphate + 5-enolpyruvylshikimate 3-phosphate	i.e. 5-O-(1-carboxyvinyl)-3-phosphoshikimate	r

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
2.5.1.19	25	-	assay at	Escherichia coli

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Release 2023.1 (January 2023)