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Literature summary extracted from

  • Allen, T.; Henschel, E.V.; Coons, T.; Cross, L.; Conley, J.; Ullman, B.
    Purification and characterization of the adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase activities from Leishmania donovani (1989), Mol. Biochem. Parasitol., 33, 273-281.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.7 AMP
-
Leishmania donovani
2.4.2.7 diphosphate
-
Leishmania donovani
2.4.2.8 diphosphate
-
Leishmania donovani
2.4.2.8 GMP
-
Leishmania donovani
2.4.2.8 GTP
-
Leishmania donovani

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.7 additional information
-
additional information
-
Leishmania donovani
2.4.2.8 additional information
-
additional information
-
Leishmania donovani

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.7 29000
-
x * 29000, SDS-PAGE Leishmania donovani
2.4.2.8 24000
-
x * 24000, SDS-PAGE Leishmania donovani

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.7 Leishmania donovani
-
APPB2 and APPB2-640A3, totally enzyme-deficient cell line, clone of APPB2 cell line
-
2.4.2.8 Leishmania donovani
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.7
-
Leishmania donovani
2.4.2.8
-
Leishmania donovani

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.7 promastigote
-
Leishmania donovani
-
2.4.2.8 promastigote
-
Leishmania donovani
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
Leishmania donovani GMP + diphosphate
-
?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
Leishmania donovani IMP + diphosphate
-
?

Subunits

EC Number Subunits Comment Organism
2.4.2.7 ? x * 29000, SDS-PAGE Leishmania donovani
2.4.2.8 ? x * 24000, SDS-PAGE Leishmania donovani