EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.198 | component 2 of dolichyl-phosphate-mannose synthase | i.e. DPM2 | Homo sapiens | |
2.4.1.198 | component 2 of dolichyl-phosphate-mannose synthase | DPM2 protein binds directly to the enzyme complex and enhances the enzyme activity, regulatory role | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.198 | expression of PIG-P in enzyme deficient mouse mutant T cell line can complement and restore the enzyme activity | Homo sapiens |
2.4.1.198 | overexpression of FLAG- and GST-double tagged PIG-A in human B lymphoblastoid JY5 cells | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.1.198 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
2.4.1.198 | endoplasmic reticulum | - |
Mus musculus | 5783 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.4.1.198 | additional information | - |
- |
Homo sapiens |
2.4.1.198 | additional information | - |
enzyme is active in a complex of at least 5 proteins, termed GPI1, PIG-P, PIG-A, PIG-C and PIG-H | Homo sapiens |
2.4.1.198 | additional information | - |
enzyme is active in a complex of at least 5 proteins, termed GPI1, PIG-P, PIG-A, PIG-C and PIG-H | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.198 | additional information | Homo sapiens | - |
? | - |
? | |
2.4.1.198 | additional information | Homo sapiens | enzyme is active in a complex of at least 5 proteins, termed GPI1, PIG-P, PIG-A, PIG-C and PIG-H, PIG-P is absolutely required | ? | - |
? | |
2.4.1.198 | additional information | Mus musculus | enzyme is active in a complex of at least 5 proteins, termed GPI1, PIG-P, PIG-A, PIG-C and PIG-H, PIG-P is absolutely required | ? | - |
? | |
2.4.1.198 | UDP-N-acetyl-D-glucosamine + phosphatidylinositol | Homo sapiens | involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
2.4.1.198 | UDP-N-acetyl-D-glucosamine + phosphatidylinositol | Mus musculus | involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.198 | Homo sapiens | - |
- |
- |
2.4.1.198 | Homo sapiens | P57054 | gene PIG-P | - |
2.4.1.198 | Homo sapiens | Q9BRB3 | - |
- |
2.4.1.198 | Mus musculus | Q9JHG1 | gene PIG-P | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.1.198 | purification of GPI1 by overexpression of PIG-A in JY5 cells and isolation of the complex by affinity chromatography | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.198 | additional information | - |
Homo sapiens | ? | - |
? | |
2.4.1.198 | additional information | enzyme is active in a complex of at least 5 proteins, termed GPI1, PIG-P, PIG-A, PIG-C and PIG-H, PIG-P is absolutely required | Homo sapiens | ? | - |
? | |
2.4.1.198 | additional information | enzyme is active in a complex of at least 5 proteins, termed GPI1, PIG-P, PIG-A, PIG-C and PIG-H, PIG-P is absolutely required | Mus musculus | ? | - |
? | |
2.4.1.198 | UDP-N-acetyl-D-glucosamine + phosphatidylinositol | enzyme complex | Homo sapiens | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
2.4.1.198 | UDP-N-acetyl-D-glucosamine + phosphatidylinositol | enzyme complex | Mus musculus | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
2.4.1.198 | UDP-N-acetyl-D-glucosamine + phosphatidylinositol | involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins | Homo sapiens | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
2.4.1.198 | UDP-N-acetyl-D-glucosamine + phosphatidylinositol | involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins | Mus musculus | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.4.1.198 | More | structure of enzyme complex, overview | Homo sapiens |
2.4.1.198 | More | structure of enzyme complex, overview | Mus musculus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.4.1.198 | 37 | - |
assay at | Homo sapiens |
2.4.1.198 | 37 | - |
assay at | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.4.1.198 | 7.4 | - |
assay at | Homo sapiens |
2.4.1.198 | 7.4 | - |
assay at | Mus musculus |