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Literature summary extracted from

  • Watanabe, R.; Inoue, N.; Westfall, B.; Taron, C.H.; Orlean, P.; Takeda, J.; Kinoshita, T.
    The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1 (1998), EMBO J., 17, 877-885.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.198 hGPI1, DNA sequence determination, coexpression as GST-tagged protein in human B lymphoblastoid JY25 or JY5 cells with the other three GST- or FLAG-tagged protein of the active protein complex Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.198 endoplasmic reticulum
-
 Homo sapiens 5783
-
2.4.1.198 endoplasmic reticulum
-
 Saccharomyces cerevisiae 5783
-
2.4.1.198 membrane
-
 Homo sapiens 16020
-
2.4.1.198 membrane
-
 Saccharomyces cerevisiae 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.198 additional information
-
-
 Saccharomyces cerevisiae
2.4.1.198 additional information
-
 enzyme is active in a complex of at least 4 proteins, termed GPI1, PIG-A, PIG-C and PIG-H, in which GPI1 is absolutely essential for stabilization Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.198 additional information Homo sapiens enzyme is active in a complex of at least 4 proteins, termed GPI1, PIG-A, PIG-C and PIG-H, in which GPI1 is absolutely essential for stabilization ?
-
 ?
2.4.1.198 additional information Saccharomyces cerevisiae glycosylphosphatidylinositol anchoring is essential for transport of cell surface proteins and enzyme deficieny leads to defective cell wall synthesis and cell death ?
-
 ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol Homo sapiens involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol Saccharomyces cerevisiae involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.198 Homo sapiens
-
-
-
2.4.1.198 Homo sapiens Q9BRB3 gene hGPI1
-
2.4.1.198 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.198 additional information enzyme is active in a complex of at least 4 proteins, termed GPI1, PIG-A, PIG-C and PIG-H, in which GPI1 is absolutely essential for stabilization Homo sapiens ?
-
 ?
2.4.1.198 additional information glycosylphosphatidylinositol anchoring is essential for transport of cell surface proteins and enzyme deficieny leads to defective cell wall synthesis and cell death Saccharomyces cerevisiae ?
-
 ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol substrate specificity Homo sapiens UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol enzyme complex Homo sapiens UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol enzyme complex Saccharomyces cerevisiae UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins Homo sapiens UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins Saccharomyces cerevisiae UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.198 GPI-GlcNAc transferase
-
 Saccharomyces cerevisiae
2.4.1.198 GPI-GlcNAc transferase
-
 Homo sapiens
2.4.1.198 GPI-GnT
-
 Saccharomyces cerevisiae
2.4.1.198 GPI-GnT
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.198 7.4
-
 assay at Homo sapiens