Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hillmen, P.; Bessler, M.; Mason, P.J.; Watkins, W.M.; Luzzatto, L.
    Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria (1993), Proc. Natl. Acad. Sci. USA, 90, 5272-5276.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.198 membrane
-
 Homo sapiens 16020
-
2.4.1.198 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.198 additional information Homo sapiens enzyme defect in paroxysmal nocturnal hemoglobinuria ?
-
 ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol Homo sapiens involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.198 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.198 lymphoblastoid cell line with paroxysmal nocturnal hemoglobinuria phenotype, i.e. PNH, obtained by Epstein-Barr immortalization of lymphocytes from PNH-patients Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.198 additional information enzyme defect in paroxysmal nocturnal hemoglobinuria Homo sapiens ?
-
 ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol
-
 Homo sapiens UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol in alpha1-6 linkage ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins Homo sapiens UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.198 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.198 7.4
-
 assay at Homo sapiens