BRENDA - Enzyme Database

Molecular cloning and characterization of lymphocyte and muscle ADP-ribosyltransferases

Okazaki, I.J.; Kim, H.J.; Moss, J.; Adv. Exp. Med. Biol. 419, 129-136 (1997)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.4.2.31
-
Homo sapiens
2.4.2.31
-
Oryctolagus cuniculus
2.4.2.31
-
Mus musculus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.4.2.31
0.118
-
NAD+
reaction with 20 mM agmatine, enzyme Yac-1
Mus musculus
2.4.2.31
0.142
-
NAD+
reaction with 20 mM agmatine, enzyme Yac-2
Mus musculus
2.4.2.31
9.4
-
agmatine
enzyme Yac-1
Mus musculus
2.4.2.31
15
-
1-(4-aminobutyl)guanidine
enzyme Yac-2
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.4.2.31
membrane
anchored to membranes by glycosylphosphatidylinositol
Homo sapiens
16020
-
2.4.2.31
membrane
anchored to membranes by glycosylphosphatidylinositol; Yac-1 enzyme is anchored to membranes by glycosylphosphatidylinositol; Yac-2 enzyme is membrane-bound but appears not to be glycosylphosphatidylinositol-anchored
Mus musculus
16020
-
2.4.2.31
membrane
anchored to membranes by glycosylphosphatidylinositol
Oryctolagus cuniculus
16020
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.31
additional information
Mus musculus
enzyme is involved in posttranslational modification of proteins
?
-
-
-
2.4.2.31
additional information
Homo sapiens
enzyme is involved in posttranslational modification of proteins
?
-
-
-
2.4.2.31
additional information
Oryctolagus cuniculus
enzyme is involved in posttranslational modification of proteins
?
-
-
-
2.4.2.31
additional information
Mus musculus
involved in immune regulation
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.31
Homo sapiens
-
-
-
2.4.2.31
Mus musculus
-
-
-
2.4.2.31
Oryctolagus cuniculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.31
lymphocyte
-
Mus musculus
-
2.4.2.31
skeletal muscle
-
Mus musculus
-
2.4.2.31
skeletal muscle
-
Oryctolagus cuniculus
-
2.4.2.31
skeletal muscle
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.31
agmatine + NAD+
-
638124
Mus musculus
nicotinamide + ?
-
-
-
-
2.4.2.31
additional information
in contrast to Yac-1, the Yac-2 enzyme has significant NAD glycohydrolase activity and may preferentially hydrolyze NAD+
638124
Mus musculus
?
-
-
-
-
2.4.2.31
additional information
enzyme is involved in posttranslational modification of proteins
638124
Mus musculus
?
-
-
-
-
2.4.2.31
additional information
enzyme is involved in posttranslational modification of proteins
638124
Homo sapiens
?
-
-
-
-
2.4.2.31
additional information
enzyme is involved in posttranslational modification of proteins
638124
Oryctolagus cuniculus
?
-
-
-
-
2.4.2.31
additional information
involved in immune regulation
638124
Mus musculus
?
-
-
-
-
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.4.2.31
-
Homo sapiens
2.4.2.31
-
Oryctolagus cuniculus
2.4.2.31
-
Mus musculus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.4.2.31
0.118
-
NAD+
reaction with 20 mM agmatine, enzyme Yac-1
Mus musculus
2.4.2.31
0.142
-
NAD+
reaction with 20 mM agmatine, enzyme Yac-2
Mus musculus
2.4.2.31
9.4
-
agmatine
enzyme Yac-1
Mus musculus
2.4.2.31
15
-
1-(4-aminobutyl)guanidine
enzyme Yac-2
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.4.2.31
membrane
anchored to membranes by glycosylphosphatidylinositol
Homo sapiens
16020
-
2.4.2.31
membrane
anchored to membranes by glycosylphosphatidylinositol; Yac-1 enzyme is anchored to membranes by glycosylphosphatidylinositol; Yac-2 enzyme is membrane-bound but appears not to be glycosylphosphatidylinositol-anchored
Mus musculus
16020
-
2.4.2.31
membrane
anchored to membranes by glycosylphosphatidylinositol
Oryctolagus cuniculus
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.31
additional information
Mus musculus
enzyme is involved in posttranslational modification of proteins
?
-
-
-
2.4.2.31
additional information
Homo sapiens
enzyme is involved in posttranslational modification of proteins
?
-
-
-
2.4.2.31
additional information
Oryctolagus cuniculus
enzyme is involved in posttranslational modification of proteins
?
-
-
-
2.4.2.31
additional information
Mus musculus
involved in immune regulation
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.31
lymphocyte
-
Mus musculus
-
2.4.2.31
skeletal muscle
-
Homo sapiens
-
2.4.2.31
skeletal muscle
-
Mus musculus
-
2.4.2.31
skeletal muscle
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.31
agmatine + NAD+
-
638124
Mus musculus
nicotinamide + ?
-
-
-
-
2.4.2.31
additional information
in contrast to Yac-1, the Yac-2 enzyme has significant NAD glycohydrolase activity and may preferentially hydrolyze NAD+
638124
Mus musculus
?
-
-
-
-
2.4.2.31
additional information
enzyme is involved in posttranslational modification of proteins
638124
Mus musculus
?
-
-
-
-
2.4.2.31
additional information
enzyme is involved in posttranslational modification of proteins
638124
Homo sapiens
?
-
-
-
-
2.4.2.31
additional information
enzyme is involved in posttranslational modification of proteins
638124
Oryctolagus cuniculus
?
-
-
-
-
2.4.2.31
additional information
involved in immune regulation
638124
Mus musculus
?
-
-
-
-