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Literature summary extracted from

  • Shibata, K.; Iwai, K.
    Crystalline quinolinate phosphoribosyltransferase from Alcaligenes eutrophus subsp. quinolinicus: effects of metal ions, phosphorous-compounds, niacin nucleotides and glycerol (1980), Agric. Biol. Chem., 44, 119-123.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.19 glycerol glycerol markedly activates enzyme activity at pH 6.1 and pH 6.5, inhibition above pH 7.0, inhibition is strongest at pH 9.0 Cupriavidus necator

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.19 5-phosphoribosyl-1-diphosphate
-
Cupriavidus necator
2.4.2.19 ADP 1 mM, 12% inhibition Cupriavidus necator
2.4.2.19 ATP 1 mM, 22% inhibition; inhibition is completely recovered by raising Mg2+ concentration Cupriavidus necator
2.4.2.19 Cd2+
-
Cupriavidus necator
2.4.2.19 CDP 1 mM, 13% inhibition Cupriavidus necator
2.4.2.19 Co2+
-
Cupriavidus necator
2.4.2.19 CTP 1 mM, 30% inhibition Cupriavidus necator
2.4.2.19 Cu2+
-
Cupriavidus necator
2.4.2.19 dTDP 1 mM, 14% inhibition Cupriavidus necator
2.4.2.19 dTTP 1 mM, 29% inhibition Cupriavidus necator
2.4.2.19 glycerol glycerol markedly activates enzyme activity at pH 6.1 and 6.5, inhibition above pH 7.0, inhibition is strongest at pH 9.0 Cupriavidus necator
2.4.2.19 GTP 1 mM, 17% inhibition Cupriavidus necator
2.4.2.19 Hg2+
-
Cupriavidus necator
2.4.2.19 ITP 1 mM, 24% inhibition Cupriavidus necator
2.4.2.19 Na4P2O7 3 mM, complete inhibition Cupriavidus necator
2.4.2.19 Ni2+
-
Cupriavidus necator
2.4.2.19 nicotinate mononucleotide 1 mM, 46% inhibition Cupriavidus necator
2.4.2.19 UTP 1 mM, 19% inhibition Cupriavidus necator
2.4.2.19 Zn2+
-
Cupriavidus necator

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.19 0.051
-
quinolinic acid in presence of 30% glycerol Cupriavidus necator
2.4.2.19 0.057
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Cupriavidus necator
2.4.2.19 0.091
-
quinolinate
-
Cupriavidus necator
2.4.2.19 0.128
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Cupriavidus necator

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.19 Cupriavidus necator
-
subsp. quinolinicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Cupriavidus necator nicotinate D-ribonucleotide + diphosphate + CO2
-
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Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.2.19 additional information
-
additional information turnover rate is decreased by adding glycerol Cupriavidus necator

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.19 0.0838
-
nicotinate mononucleotide
-
Cupriavidus necator
2.4.2.19 0.265
-
5-phosphoribosyl-1-diphosphate
-
Cupriavidus necator