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Literature summary extracted from

  • Iwai, K.; Shibata, K.; Taguchi, H.; Itakura, T.
    Properties of crystalline quinolinate phosphoribosyltransferase from Alcaligenes eutrophus nov. Subsp. Quinolinicus (1979), Agric. Biol. Chem., 43, 345-350.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.19 H2PO4-
-
 Cupriavidus necator

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.19 0.111
-
 5-phospho-alpha-D-ribose 1-diphosphate
-
 Cupriavidus necator
2.4.2.19 0.133
-
 quinolinate
-
 Cupriavidus necator

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.19 Mg2+ absolute requirement for a divalent metal ion, Mg2+ is most effective, optimal activity at 1.5 mM Cupriavidus necator
2.4.2.19 Mn2+ at 1 mM, 80% of the activation with Mg2+ Cupriavidus necator

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.19 27500
-
 8 * 27500, SDS-PAGE Cupriavidus necator
2.4.2.19 210000
-
 gel filtration Cupriavidus necator

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.19 Cupriavidus necator
-
 nov. subsp. quinolinicus
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.2.19 beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate formation of a ternary complex comprising the enzyme, quinolinate and 5-phosphoribosyl-1-diphosphate Cupriavidus necator
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Cupriavidus necator nicotinate D-ribonucleotide + diphosphate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.19 octamer 8 * 27500, SDS-PAGE Cupriavidus necator

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.19 60
-
-
 Cupriavidus necator

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.19 8.5 9
-
 Cupriavidus necator