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Literature summary extracted from

  • Shibata, K.; Iwai, K.
    Isolation and properties of crystalline quinolinate phosphoribosyltransferase from hog kidney (1980), Biochim. Biophys. Acta, 611, 280-288.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.19 2-oxoglutarate 1 mM, 55% inhibition Sus scrofa
2.4.2.19 acetic acid 26% inhibition Sus scrofa
2.4.2.19 aspartic acid 1 mM, 37% inhibition Sus scrofa
2.4.2.19 Citric acid 1 mM, 89% inhibition Sus scrofa
2.4.2.19 formic acid 1 mM, 54% inhibition Sus scrofa
2.4.2.19 Fumaric acid 1 mM, 67% inhibition Sus scrofa
2.4.2.19 L-Glutamic acid 1 mM, 41% inhibition Sus scrofa
2.4.2.19 L-Malic acid 1 mM, 67% inhibition Sus scrofa
2.4.2.19 Lactic acid 1 mM, 29% inhibition Sus scrofa
2.4.2.19 Maleic acid 1 mM, 42% inhibition Sus scrofa
2.4.2.19 oxaloacetic acid 1 mM, 59% inhibition Sus scrofa
2.4.2.19 succinic acid 1 mM, 46% inhibition Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.19 0.04
-
 quinolinate
-
 Sus scrofa
2.4.2.19 0.14
-
 5-phospho-alpha-D-ribose 1-diphosphate
-
 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.19 Mg2+ absolute requirement for divalent cations. Mg2+ is most effective. Optimal concentrations are 4, 6 and 10 mM for 20, 40 and 100 mM sodium acetate/acetic acid buffer, pH 5.5 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.19 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.2.19 glycoprotein enzyme contains 1% mannose Sus scrofa

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.19
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.19 kidney
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.19 0.091
-
-
 Sus scrofa

Storage Stability

EC Number Storage Stability Organism
2.4.2.19 0-4°C, crystalline enzyme is stable for at least 2 years Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Sus scrofa nicotinate D-ribonucleotide + diphosphate + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.19 5.5
-
-
 Sus scrofa

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.4.2.19 3 3.5 37°C, denatured abruptly Sus scrofa
2.4.2.19 4.5 9.5 37°C, 30 min, completely stable Sus scrofa