EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.2.19 | - |
Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.19 | D-fructose-1,6-diphosphate | competitive with respect to 5-phosphoribosyl-1-diphosphate and noncompetitive with respect to quinolinate | Escherichia coli | |
2.4.2.19 | diphosphate | noncompetitive with respect to both 5-phosphoribosyl-1-diphosphate and quinolinate | Escherichia coli | |
2.4.2.19 | nicotinate mononucleotide | competitive with respect to 5-phosphoribosyl-1-diphosphate | Escherichia coli | |
2.4.2.19 | Phthalic acid | dead-end inhibitor, competitive with respect to quinolinate, uncompetitive with respect to 5-phosphoribosyl-1-diphosphate | Escherichia coli |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.19 | 0.0064 | - |
quinolinate | - |
Escherichia coli | |
2.4.2.19 | 0.0156 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Escherichia coli |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.19 | Mg2+ | required | Escherichia coli |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.4.2.19 | 36000 | - |
2 * 36000, SDS-PAGE | Escherichia coli |
2.4.2.19 | 70000 | - |
gel filtration | Escherichia coli |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.19 | Escherichia coli | P30011 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.2.19 | - |
Escherichia coli |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.4.2.19 | beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | ordered binding mechanism | Escherichia coli |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.4.2.19 | additional information | - |
- |
Escherichia coli |
EC Number | Storage Stability | Organism |
---|---|---|
2.4.2.19 | 4°C, stable for 1 month | Escherichia coli |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.19 | pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Escherichia coli | nicotinate D-ribonucleotide + diphosphate + CO2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.4.2.19 | dimer | 2 * 36000, SDS-PAGE | Escherichia coli |