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Literature summary extracted from

  • Naguib, F.N.M.; Iltzsch, M.H.; el Kouni, M.M.; Panzica, R.P.; el Kouni, M.H.
    Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii (1995), Biochem. Pharmacol., 50, 1685-1693.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.22 2,6-diaminopurine
-
 Toxoplasma gondii
2.4.2.22 2,6-dichloropurine
-
 Toxoplasma gondii
2.4.2.22 2,6-dioxo-1,3,7-trimethylpurine
-
 Toxoplasma gondii
2.4.2.22 2,6-dioxo-1,3,9-trimethylpurine
-
 Toxoplasma gondii
2.4.2.22 2,6-dioxo-3-isobutyl-1-methylpurine
-
 Toxoplasma gondii
2.4.2.22 2,6-dioxo-7-(beta-hydroxypropyl)-1,3-dimethylpurine
-
 Toxoplasma gondii
2.4.2.22 2,6-dithiopurine
-
 Toxoplasma gondii
2.4.2.22 2-amino-1-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-amino-1-methylpurine
-
 Toxoplasma gondii
2.4.2.22 2-amino-6-chloropurine
-
 Toxoplasma gondii
2.4.2.22 2-amino-7-deazahypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-amino-7-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-amino-9-deazahypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-amino-9-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-aminohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-Aminopurine
-
 Toxoplasma gondii
2.4.2.22 2-aminopurine-6-thione
-
 Toxoplasma gondii
2.4.2.22 2-aza-3-deazahypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-aza-6-amino-3-deazapurine
-
 Toxoplasma gondii
2.4.2.22 2-aza-6-thio-3-deazapurine
-
 Toxoplasma gondii
2.4.2.22 2-oxo 7-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-oxo-1-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-oxo-3-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-oxo-6-thiopurine
-
 Toxoplasma gondii
2.4.2.22 2-oxohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2-oxohypoxanthine-N3-oxide
-
 Toxoplasma gondii
2.4.2.22 2-oxopurine
-
 Toxoplasma gondii
2.4.2.22 2-thiohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 4-oxopyrimidine
-
 Toxoplasma gondii
2.4.2.22 5(4)-amino-4-imidazolecarboxamide
-
 Toxoplasma gondii
2.4.2.22 5-fluorocytosine
-
 Toxoplasma gondii
2.4.2.22 6-amino-1-methylpurine
-
 Toxoplasma gondii
2.4.2.22 6-amino-2,8-diaza-3-deazapurine
-
 Toxoplasma gondii
2.4.2.22 6-amino-2-chloropurine
-
 Toxoplasma gondii
2.4.2.22 6-amino-2-methylpurine
-
 Toxoplasma gondii
2.4.2.22 6-amino-2-oxopurine
-
 Toxoplasma gondii
2.4.2.22 6-amino-7-deazapurine
-
 Toxoplasma gondii
2.4.2.22 6-amino-8-bromopurine
-
 Toxoplasma gondii
2.4.2.22 6-benzylaminopurine
-
 Toxoplasma gondii
2.4.2.22 6-Chloropurine
-
 Toxoplasma gondii
2.4.2.22 6-Hydroxymethylpterin
-
 Toxoplasma gondii
2.4.2.22 6-methoxypurine
-
 Toxoplasma gondii
2.4.2.22 6-Methylaminopurine
-
 Toxoplasma gondii
2.4.2.22 6-Thiopurine
-
 Toxoplasma gondii
2.4.2.22 8-aza-1,3-dideazapurine
-
 Toxoplasma gondii
2.4.2.22 8-aza-1-nitro-1,3-dideazapurine
-
 Toxoplasma gondii
2.4.2.22 8-aza-2,6-diaminopurine
-
 Toxoplasma gondii
2.4.2.22 8-aza-2-aminohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 8-aza-6-aminopurine
-
 Toxoplasma gondii
2.4.2.22 8-aza-7-deaza-6-aminopurine
-
 Toxoplasma gondii
2.4.2.22 8-aza-7-deaza-6-thiopurine
-
 Toxoplasma gondii
2.4.2.22 8-aza-7-deazahypoxanthine
-
 Toxoplasma gondii
2.4.2.22 8-Azahypoxanthine
-
 Toxoplasma gondii
2.4.2.22 8-bromo-2-aminohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 8-oxohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 8-thiohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 adenine
-
 Toxoplasma gondii
2.4.2.22 Benzonitrile
-
 Toxoplasma gondii
2.4.2.22 cytosine
-
 Toxoplasma gondii
2.4.2.22 guanine
-
 Toxoplasma gondii
2.4.2.22 hypoxanthine
-
 Toxoplasma gondii
2.4.2.22 isocytosine
-
 Toxoplasma gondii
2.4.2.22 Uracil
-
 Toxoplasma gondii
2.4.2.22 xanthine
-
 Toxoplasma gondii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.22 0.0012
-
 hypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.0013
-
 guanine
-
 Toxoplasma gondii
2.4.2.22 0.0029
-
 adenine
-
 Toxoplasma gondii
2.4.2.22 0.003
-
 xanthine
-
 Toxoplasma gondii

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.22 Toxoplasma gondii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + adenine less than 1% of the activity with xanthine Toxoplasma gondii AMP + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + guanine
-
 Toxoplasma gondii GMP + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
-
 Toxoplasma gondii IMP + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
-
 Toxoplasma gondii 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.22 7.5
-
 reaction with hypoxanthine and guanine Toxoplasma gondii
2.4.2.22 7.8
-
 reaction with xanthine Toxoplasma gondii
2.4.2.22 8 9.5 reaction with adenine Toxoplasma gondii

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.22 0.002
-
 2-aminopurine-6-thione
-
 Toxoplasma gondii
2.4.2.22 0.0035
-
 hypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.006
-
 6-Thiopurine
-
 Toxoplasma gondii
2.4.2.22 0.0079
-
 5(4)-amino-4-imidazolecarboxamide
-
 Toxoplasma gondii
2.4.2.22 0.012
-
 2-aminohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.014
-
 2-amino-9-deazahypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.014
-
 2-oxohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.022
-
 2-aza-3-deazahypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.026
-
 2-amino-7-deazahypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.03
-
 2-aza-6-thio-3-deazapurine
-
 Toxoplasma gondii
2.4.2.22 0.035
-
 8-aza-7-deazahypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.04
-
 2-amino 1-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.053
-
 6-amino-2-oxopurine
-
 Toxoplasma gondii
2.4.2.22 0.067
-
 2-Aminopurine
-
 Toxoplasma gondii
2.4.2.22 0.068
-
 2-thiohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.081
-
 8-aza-7-deaza-6-aminopurine
-
 Toxoplasma gondii
2.4.2.22 0.1
-
 6-Chloropurine
-
 Toxoplasma gondii
2.4.2.22 0.23
-
 2-amino-6-chloropurine
-
 Toxoplasma gondii
2.4.2.22 0.23
-
 2-amino-9-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.231
-
 2-aza-6-amino-3-deazapurine
-
 Toxoplasma gondii
2.4.2.22 0.246
-
 2-oxo-6-thiopurine
-
 Toxoplasma gondii
2.4.2.22 0.286
-
 cytosine
-
 Toxoplasma gondii
2.4.2.22 0.29
-
 2-amino 1-methylpurine
-
 Toxoplasma gondii
2.4.2.22 0.31
-
 6-amino 1-methylpurine
-
 Toxoplasma gondii
2.4.2.22 0.37
-
 6-amino-2-methylpurine
-
 Toxoplasma gondii
2.4.2.22 0.379
-
 4-oxopyrimidine
-
 Toxoplasma gondii
2.4.2.22 0.38
-
 6-methoxypurine
-
 Toxoplasma gondii
2.4.2.22 0.39
-
 8-aza-1-nitro-1,3-dideazapurine
-
 Toxoplasma gondii
2.4.2.22 0.41
-
 2,6-dichloropurine
-
 Toxoplasma gondii
2.4.2.22 0.42
-
 2,6-dithiopurine
-
 Toxoplasma gondii
2.4.2.22 0.42
-
 8-thiohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.437
-
 6-amino-2,8-diaza-3-deazapurine
-
 Toxoplasma gondii
2.4.2.22 0.54
-
 8-bromo-2-aminohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 0.57
-
 2-oxopurine
-
 Toxoplasma gondii
2.4.2.22 0.657
-
 5-fluorocytosine
-
 Toxoplasma gondii
2.4.2.22 0.75
-
 6-amino-8-bromopurine
-
 Toxoplasma gondii
2.4.2.22 0.808
-
 Uracil
-
 Toxoplasma gondii
2.4.2.22 0.85
-
 8-aza-2,6-diaminopurine
-
 Toxoplasma gondii
2.4.2.22 0.87
-
 Benzonitrile
-
 Toxoplasma gondii
2.4.2.22 0.88
-
 8-aza-7-deaza 6-thiopurine
-
 Toxoplasma gondii
2.4.2.22 0.97
-
 6-Methylaminopurine
-
 Toxoplasma gondii
2.4.2.22 1
-
 2,6-dioxo-1,3,7-trimethylpurine
-
 Toxoplasma gondii
2.4.2.22 1.06
-
 isocytosine
-
 Toxoplasma gondii
2.4.2.22 1.1
-
 6-benzylaminopurine
-
 Toxoplasma gondii
2.4.2.22 1.3
-
 2-oxohypoxanthine-N3-oxide
-
 Toxoplasma gondii
2.4.2.22 1.4
-
 2-oxo 1-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 1.5
-
 2,6-dioxo 3-isobutyl-1-methylpurine
-
 Toxoplasma gondii
2.4.2.22 1.7
-
 6-amino-7-deazapurine
-
 Toxoplasma gondii
2.4.2.22 1.9
-
 2,6-dioxo-7-(beta-hydroxypropyl)-1,3-dimethylpurine
-
 Toxoplasma gondii
2.4.2.22 1.9
-
 2-oxo 7-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2
-
 8-Azahypoxanthine
-
 Toxoplasma gondii
2.4.2.22 2.2
-
 6-amino-2-chloropurine
-
 Toxoplasma gondii
2.4.2.22 2.5
-
 8-aza-6-aminopurine
-
 Toxoplasma gondii
2.4.2.22 2.6
-
 8-aza-2-aminohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 3.1
-
 2-amino-7-methylhypoxanthine
-
 Toxoplasma gondii
2.4.2.22 3.4
-
 6-Hydroxymethylpterin
-
 Toxoplasma gondii
2.4.2.22 4.1
-
 8-oxohypoxanthine
-
 Toxoplasma gondii
2.4.2.22 5.2
-
 8-aza-1,3-dideazapurine
-
 Toxoplasma gondii
2.4.2.22 5.3
-
 2,6-dioxo-1,3,9-trimethylpurine
-
 Toxoplasma gondii