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Literature summary extracted from

  • Kidder, G.W.; Nolan, L.L.
    Xanthine phosphoribosyltransferase in Leishmania: divalent cation activation (1982), J. Protozool., 29, 405-409.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.22 Co2+ less efficient in activation than Mn2+ Leishmania donovani
2.4.2.22 Co2+ less efficient in activation than Mn2+ Leishmania tarentolae
2.4.2.22 Co2+ efficiency is equal to Mn2+ Leishmania mexicana
2.4.2.22 Co2+ efficiency is equal to Mn2+ Leishmania braziliensis
2.4.2.22 Mg2+ very low activation Leishmania donovani
2.4.2.22 Mg2+ very low activation Leishmania tarentolae
2.4.2.22 Mg2+ very low activation Leishmania mexicana
2.4.2.22 Mg2+ very low activation Leishmania braziliensis
2.4.2.22 Mn2+ efficient activation Leishmania donovani
2.4.2.22 Mn2+ efficient activation Leishmania tarentolae
2.4.2.22 Mn2+ efficient activation Leishmania mexicana
2.4.2.22 Mn2+ efficient activation Leishmania braziliensis
2.4.2.22 Zn2+ very low activation Leishmania donovani
2.4.2.22 Zn2+ very low activation Leishmania tarentolae
2.4.2.22 Zn2+ very low activation Leishmania mexicana
2.4.2.22 Zn2+ very low activation Leishmania braziliensis

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.22 Leishmania braziliensis
-
-
-
2.4.2.22 Leishmania donovani
-
-
-
2.4.2.22 Leishmania mexicana
-
-
-
2.4.2.22 Leishmania tarentolae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.22 promastigote
-
 Leishmania donovani
-
2.4.2.22 promastigote
-
 Leishmania tarentolae
-
2.4.2.22 promastigote
-
 Leishmania mexicana
-
2.4.2.22 promastigote
-
 Leishmania braziliensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + guanine
-
 Leishmania donovani GMP + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + guanine
-
 Leishmania mexicana GMP + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
-
 Leishmania donovani IMP + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
-
 Leishmania mexicana IMP + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
-
 Leishmania donovani 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
-
 Leishmania tarentolae 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
-
 Leishmania braziliensis 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + xanthine the enzymes catalyzing the transribosylation from 5-phospho-alpha-D-ribose 1-diphosphate to guanine, hypoxanthine and xanthine are inseparable Leishmania mexicana 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?