BRENDA - Enzyme Database show

Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo

Rankin, P.W.; Jacobson, E.L.; benjamin, R.C.; Moss, J.; Jacobson, M.K.; J. Biol. Chem. 264, 4312-4317 (1989)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.30
1-methylnicotinamide chloride
IC50: 1.7 mM
Bos taurus
2.4.2.30
2-Aminobenzamide
IC50: 0.1 mM
Bos taurus
2.4.2.30
3-aminobenzamide
IC50: 0.0054
Bos taurus
2.4.2.30
3-isobutyl-1-methylxanthine
IC50: 3.1 mM
Bos taurus
2.4.2.30
3-Methoxybenzamide
IC50: 0.0034 mM
Bos taurus
2.4.2.30
4-Aminobenzamide
IC50: 0.4 mM
Bos taurus
2.4.2.30
5-bromodeoxyuridine
IC50: 0.015 mM
Bos taurus
2.4.2.30
5-Methylnicotinamide
IC50: 0.07
Bos taurus
2.4.2.30
8-Methylnicotinamide
IC50: 7.8 mM
Bos taurus
2.4.2.30
Benzamide
IC50: 0.0033 mM
Bos taurus
2.4.2.30
Caffeine
IC50: 1.4 mM
Bos taurus
2.4.2.30
hypoxanthine
IC50: 1.7 mM
Bos taurus
2.4.2.30
Isonicotinate hydrazide
IC50: 4.8 MM
Bos taurus
2.4.2.30
nicotinamide
IC50: 0.031 mM
Bos taurus
2.4.2.30
Pyrazinamide
IC50: 0.13 mM
Bos taurus
2.4.2.30
Theobromine
IC50: 0.11 mM
Bos taurus
2.4.2.30
theophylline
IC50: 0.0046
Bos taurus
2.4.2.30
thymidine
IC50: 0.043
Bos taurus
2.4.2.30
Zn2+
ZnCl2, IC50: 0.077 mM
Bos taurus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.30
Bos taurus
-
calf
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.30
thymus
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.30
NAD+ + (ADP-D-ribosyl)n-acceptor
-
638001
Bos taurus
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.4.2.30
0.0033
-
IC50: 0.0033 mM
Bos taurus
Benzamide
2.4.2.30
0.0034
-
IC50: 0.0034 mM
Bos taurus
3-Methoxybenzamide
2.4.2.30
0.0054
-
IC50: 0.0054
Bos taurus
3-aminobenzamide
2.4.2.30
0.015
-
IC50: 0.015 mM
Bos taurus
5-bromodeoxyuridine
2.4.2.30
0.031
-
IC50: 0.031 mM
Bos taurus
nicotinamide
2.4.2.30
0.043
-
IC50: 0.043 mM
Bos taurus
thymidine
2.4.2.30
0.046
-
IC50: 0.046 mM
Bos taurus
theophylline
2.4.2.30
0.07
-
IC50: 0.07 mM
Bos taurus
5-Methylnicotinamide
2.4.2.30
0.077
-
ZnCl2, IC50: 0.077 mM
Bos taurus
Zn2+
2.4.2.30
0.1
-
IC50: 0.1 mM
Bos taurus
2-Aminobenzamide
2.4.2.30
0.11
-
IC50: 0.11 mM
Bos taurus
Theobromine
2.4.2.30
0.13
-
IC50: 0.13 mM
Bos taurus
Pyrazinamide
2.4.2.30
0.4
-
IC50: 0.4 mM
Bos taurus
4-Aminobenzamide
2.4.2.30
1.4
-
IC50: 1.4 mM
Bos taurus
Caffeine
2.4.2.30
1.7
-
IC50: 1.7 mM
Bos taurus
1-methylnicotinamide chloride
2.4.2.30
1.7
-
IC50: 1.7 mM
Bos taurus
hypoxanthine
2.4.2.30
3.1
-
IC50: 3.1 mM
Bos taurus
3-isobutyl-1-methylxanthine
2.4.2.30
4.8
-
IC50: 4.8 mM
Bos taurus
Isonicotinate hydrazide
2.4.2.30
7.8
-
IC50: 7.8 mM
Bos taurus
8-Methylnicotinamide
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.4.2.30
0.0033
-
IC50: 0.0033 mM
Bos taurus
Benzamide
2.4.2.30
0.0034
-
IC50: 0.0034 mM
Bos taurus
3-Methoxybenzamide
2.4.2.30
0.0054
-
IC50: 0.0054
Bos taurus
3-aminobenzamide
2.4.2.30
0.015
-
IC50: 0.015 mM
Bos taurus
5-bromodeoxyuridine
2.4.2.30
0.031
-
IC50: 0.031 mM
Bos taurus
nicotinamide
2.4.2.30
0.043
-
IC50: 0.043 mM
Bos taurus
thymidine
2.4.2.30
0.046
-
IC50: 0.046 mM
Bos taurus
theophylline
2.4.2.30
0.07
-
IC50: 0.07 mM
Bos taurus
5-Methylnicotinamide
2.4.2.30
0.077
-
ZnCl2, IC50: 0.077 mM
Bos taurus
Zn2+
2.4.2.30
0.1
-
IC50: 0.1 mM
Bos taurus
2-Aminobenzamide
2.4.2.30
0.11
-
IC50: 0.11 mM
Bos taurus
Theobromine
2.4.2.30
0.13
-
IC50: 0.13 mM
Bos taurus
Pyrazinamide
2.4.2.30
0.4
-
IC50: 0.4 mM
Bos taurus
4-Aminobenzamide
2.4.2.30
1.4
-
IC50: 1.4 mM
Bos taurus
Caffeine
2.4.2.30
1.7
-
IC50: 1.7 mM
Bos taurus
1-methylnicotinamide chloride
2.4.2.30
1.7
-
IC50: 1.7 mM
Bos taurus
hypoxanthine
2.4.2.30
3.1
-
IC50: 3.1 mM
Bos taurus
3-isobutyl-1-methylxanthine
2.4.2.30
4.8
-
IC50: 4.8 mM
Bos taurus
Isonicotinate hydrazide
2.4.2.30
7.8
-
IC50: 7.8 mM
Bos taurus
8-Methylnicotinamide
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.30
1-methylnicotinamide chloride
IC50: 1.7 mM
Bos taurus
2.4.2.30
2-Aminobenzamide
IC50: 0.1 mM
Bos taurus
2.4.2.30
3-aminobenzamide
IC50: 0.0054
Bos taurus
2.4.2.30
3-isobutyl-1-methylxanthine
IC50: 3.1 mM
Bos taurus
2.4.2.30
3-Methoxybenzamide
IC50: 0.0034 mM
Bos taurus
2.4.2.30
4-Aminobenzamide
IC50: 0.4 mM
Bos taurus
2.4.2.30
5-bromodeoxyuridine
IC50: 0.015 mM
Bos taurus
2.4.2.30
5-Methylnicotinamide
IC50: 0.07
Bos taurus
2.4.2.30
8-Methylnicotinamide
IC50: 7.8 mM
Bos taurus
2.4.2.30
Benzamide
IC50: 0.0033 mM
Bos taurus
2.4.2.30
Caffeine
IC50: 1.4 mM
Bos taurus
2.4.2.30
hypoxanthine
IC50: 1.7 mM
Bos taurus
2.4.2.30
Isonicotinate hydrazide
IC50: 4.8 MM
Bos taurus
2.4.2.30
nicotinamide
IC50: 0.031 mM
Bos taurus
2.4.2.30
Pyrazinamide
IC50: 0.13 mM
Bos taurus
2.4.2.30
Theobromine
IC50: 0.11 mM
Bos taurus
2.4.2.30
theophylline
IC50: 0.0046
Bos taurus
2.4.2.30
thymidine
IC50: 0.043
Bos taurus
2.4.2.30
Zn2+
ZnCl2, IC50: 0.077 mM
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.30
thymus
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.30
NAD+ + (ADP-D-ribosyl)n-acceptor
-
638001
Bos taurus
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
-
?