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Literature summary extracted from

  • Schweiger, M.; Auer, B.; Burtscher, H.J.; Hirsch-Kauffmann, M.; Klocker, H.; Schneider, R.
    The Fritz-Lipmann lecture. DNA repair in human cells. Biochemistry of the hereditary diseases Fanconis anaemia and Cockayne syndrome (1987), Eur. J. Biochem., 165, 235-242.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.30 nucleus
-
 Homo sapiens 5634
-
2.4.2.30 polysome
-
 Homo sapiens 5844
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 additional information Homo sapiens ADP-ribosylation seems to be involved in regulation of differentiation, the enzyme may be centrally involved in tumorigenic cell transformation, the enzyme appears to be a central controller of cell processes: higher activities shift the cell towards proliferation, low activities shift the cell towards differentiation, role of the enzyme in DNA repair ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.30
-
 Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.30 0.325
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 additional information ADP-ribosylation seems to be involved in regulation of differentiation, the enzyme may be centrally involved in tumorigenic cell transformation, the enzyme appears to be a central controller of cell processes: higher activities shift the cell towards proliferation, low activities shift the cell towards differentiation, role of the enzyme in DNA repair Homo sapiens ?
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation of topoisomerase I Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation of high mobility group proteins Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation of DNA ligase Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation of endonuclease Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation of topoisomerase II Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation of terminal deoxynucleotidyltransferase Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation of histone Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation of ADP-ribosyltransferase Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?