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Literature summary extracted from

  • Higgins, E.A.; Siminovitch, K.A.; Zhuang, D.; Brockhausen, I.; Dennis, J.W.
    Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome (1991), J. Biol. Chem., 266, 6280-6290.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.146 microsome
-
Homo sapiens
-
-
2.4.3.7 membrane
-
Homo sapiens 16020
-
2.4.3.7 microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.102 additional information Homo sapiens patients with Wiskott-Aldrich-Syndrome show an altered enzyme activity and inversed enzyme stimulation in T cells, enzyme activity in platelets is 3fold higher compared to normal organisms ?
-
?
2.4.3.7 CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R Homo sapiens pathway in glycoprotein biosynthesis CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetylneuraminyl-2,6)-N-acetyl-D-galactosaminyl-R
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.102 Homo sapiens
-
-
-
2.4.1.146 Homo sapiens
-
-
-
2.4.3.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.102 B-cell
-
Homo sapiens
-
2.4.1.102 blood platelet
-
Homo sapiens
-
2.4.1.102 T-lymphocyte
-
Homo sapiens
-
2.4.1.146 B-cell EBV immortilized B-cell line, from normal patients and such with the Wiskott-Aldrich syndrome Homo sapiens
-
2.4.3.7 B-cell Epstein-Barr virus transformed cell line Homo sapiens
-
2.4.3.7 platelet
-
Homo sapiens
-
2.4.3.7 T-lymphocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.102 0.000013
-
unstimulated normal T-lymphocytes Homo sapiens
2.4.1.102 0.00004
-
EBV B-cell line from healthy individuals Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.102 additional information patients with Wiskott-Aldrich-Syndrome show an altered enzyme activity and inversed enzyme stimulation in T cells, enzyme activity in platelets is 3fold higher compared to normal organisms Homo sapiens ?
-
?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
-
Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
?
2.4.1.146 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
?
2.4.1.146 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
?
2.4.3.7 CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R pathway in glycoprotein biosynthesis Homo sapiens CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetylneuraminyl-2,6)-N-acetyl-D-galactosaminyl-R
-
?
2.4.3.7 CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
-
Homo sapiens CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetylneuraminyl-2,6)-N-acetyl-D-galactosaminyl-R
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.146 beta3GlcNAc-T (elongation)
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.146 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.146 6.7
-
assay at Homo sapiens