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Literature summary extracted from

  • Berhane, K.; Widersten, M.; Engstroem, A.; Kozarich, J.W.; Mannervik, B.
    Detoxication of base propenals and other alpha,beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases (1994), Proc. Natl. Acad. Sci. USA, 91, 1480-1484.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.18
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.18 S-hexylglutathione
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.18 P1-1, A1-1 and M1-1 Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.18 0.7
-
 with adenine propenal, isoenzyme A1-1 Homo sapiens
2.5.1.18 0.86
-
 with acrolein, isoenzyme A1-1 Homo sapiens
2.5.1.18 3.7
-
 with adenine propenal, isoenzyme M1-1 Homo sapiens
2.5.1.18 7.05
-
 with acrolein, isoenzyme M1-1 Homo sapiens
2.5.1.18 26.3
-
 with acrolein, isoenzyme P1-1 Homo sapiens
2.5.1.18 77
-
 with adenine propenal, isoenzyme P1-1 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + acrolein
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + adenine propenal
-
 Homo sapiens ?
-
 ?
2.5.1.18 additional information conjugation of glutathione with base propenals and related alkenes, A1-1 and M1-1 are more active with 4-hydroxyalkenals than with base propenals Homo sapiens ?
-
 ?