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Literature summary extracted from

  • Hayakawa, T.; Myokei, Y.; Yagi, H.; Jerina, D.M.
    Purification and some properties of glutathione-S-epoxide transferase from guinea pig liver (1977), J. Biochem., 82, 407-415.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.18 epichlorohydrin 3 mM, competitive Cavia porcellus
2.5.1.18 guanidine hydrochloride denaturation at 6 M Cavia porcellus
2.5.1.18 naphthalene oxide 0.09 mM, competitive Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.18 additional information
-
 additional information
-
 Cavia porcellus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.18 25000
-
 2 * 25000, SDS-PAGE Cavia porcellus
2.5.1.18 45000 47000 sedimentation equilibrium analysis, gel filtration Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Cavia porcellus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.18
-
 Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 liver
-
 Cavia porcellus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.18 additional information
-
-
 Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 4-nitrobenzyl chloride
-
 Cavia porcellus ?
-
 ?
2.5.1.18 glutathione + indomethane
-
 Cavia porcellus ?
-
 ?
2.5.1.18 glutathione + naphthalene oxide
-
 Cavia porcellus ?
-
 ?
2.5.1.18 glutathione + styrene oxide
-
 Cavia porcellus ?
-
 ?
2.5.1.18 RX + glutathione RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange Cavia porcellus HX + R-S-glutathione
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.18 dimer 2 * 25000, SDS-PAGE Cavia porcellus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.18 0.037
-
 naphthalene oxide
-
 Cavia porcellus
2.5.1.18 1.49
-
 epichlorohydrin
-
 Cavia porcellus