EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.18 | bromosulfophthalein | - |
Rattus norvegicus | |
2.5.1.18 | Cibacron blue | - |
Rattus norvegicus | |
2.5.1.18 | Hematin | - |
Rattus norvegicus | |
2.5.1.18 | indomethacin | - |
Rattus norvegicus | |
2.5.1.18 | Rose bengal | - |
Rattus norvegicus | |
2.5.1.18 | S-(4-Bromobenzyl)glutathione | - |
Rattus norvegicus | |
2.5.1.18 | sulfophthalein | - |
Rattus norvegicus | |
2.5.1.18 | Tributyltin acetate | - |
Rattus norvegicus | |
2.5.1.18 | Triethyltin bromide | - |
Rattus norvegicus | |
2.5.1.18 | Triphenyltin chloride | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.18 | additional information | - |
additional information | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.5.1.18 | cytosol | - |
Rattus norvegicus | 5829 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.18 | RX + glutathione | Rattus norvegicus | detoxification of products of oxidative metabolism, e.g. 4-hydroxyalkenals, epoxides, organic hydroperoxides | HX + R-S-glutathione | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.18 | Rattus norvegicus | - |
male specific-pathogen-free Sprague Dawley | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.5.1.18 | 7 major isoenzymes | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.5.1.18 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.5.1.18 | 16.7 | 64.1 | with 1-chloro-2,4-dinitrobenzene as substrate | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.18 | glutathione + 1,2-dichloro-4-nitrobenzene | - |
Rattus norvegicus | ? | - |
? | |
2.5.1.18 | glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane | - |
Rattus norvegicus | ? | - |
? | |
2.5.1.18 | glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rattus norvegicus | S-2,4-dinitrophenylglutathione + HCl | - |
? | |
2.5.1.18 | glutathione + 4-nitrophenyl acetate | - |
Rattus norvegicus | ? | - |
? | |
2.5.1.18 | glutathione + androst-5-ene-3,17-dione | - |
Rattus norvegicus | ? | - |
? | |
2.5.1.18 | glutathione + cumene hydroperoxide | - |
Rattus norvegicus | ? | - |
? | |
2.5.1.18 | glutathione + ethacrynic acid | - |
Rattus norvegicus | ? | - |
? | |
2.5.1.18 | glutathione + trans-4-phenyl-3-buten-2-one | - |
Rattus norvegicus | ? | - |
? | |
2.5.1.18 | additional information | specificity | Rattus norvegicus | ? | - |
? | |
2.5.1.18 | RX + glutathione | RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange | Rattus norvegicus | HX + R-S-glutathione | - |
? | |
2.5.1.18 | RX + glutathione | detoxification of products of oxidative metabolism, e.g. 4-hydroxyalkenals, epoxides, organic hydroperoxides | Rattus norvegicus | HX + R-S-glutathione | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.5.1.18 | 30 | - |
assay at | Rattus norvegicus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.18 | 27 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 4-4, cofactor: glutathione | Rattus norvegicus | |
2.5.1.18 | 54 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 3-3, cofactor: glutathione | Rattus norvegicus | |
2.5.1.18 | 63 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 1-2, cofactor: glutathione | Rattus norvegicus | |
2.5.1.18 | 65 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 3-4, cofactor: glutathione | Rattus norvegicus | |
2.5.1.18 | 78 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 1-1, cofactor: glutathione | Rattus norvegicus | |
2.5.1.18 | 82 | - |
1-chloro-2,4-dinitrobenzene | isoenzyme 3-?, cofactor: glutathione | Rattus norvegicus |