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Literature summary extracted from

  • Morgenstern, R.; Guthenberg, C.; DePierre, J.W.
    Microsomal glutathione S-transferase. Purification, initial characterization and demonstration that it is not identical to the cytosolic glutathione S-transferases A, B and C (1982), Eur. J. Biochem., 128, 243-248.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.18 microsome
-
 Rattus norvegicus
-
-
2.5.1.18 additional information microsomal enzyme is clearly distinct from cytosolic Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.18 14000
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.18 RX + glutathione Rattus norvegicus participates in detoxification HX + R-S-glutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.18 36fold Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.18 30.9
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1,2-dichloro-4-nitrobenzene
-
 Rattus norvegicus ?
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Rattus norvegicus S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 additional information no substrate: bromosulfophthalein Rattus norvegicus ?
-
 ?
2.5.1.18 additional information no substrate: 4-nitrobenzyl chloride Rattus norvegicus ?
-
 ?
2.5.1.18 additional information no substrate: 1,2-epoxy-3-(4-nitrophenoxy)propane Rattus norvegicus ?
-
 ?
2.5.1.18 additional information no substrate: trans-4-phenyl-3-buten-2-one Rattus norvegicus ?
-
 ?
2.5.1.18 additional information no substrate: ethacrynic acid Rattus norvegicus ?
-
 ?
2.5.1.18 RX + glutathione RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange Rattus norvegicus HX + R-S-glutathione
-
 ?
2.5.1.18 RX + glutathione participates in detoxification Rattus norvegicus HX + R-S-glutathione
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.18 More more than one subunit Rattus norvegicus